Evidence map›Paper›PMID 31788734›Full record

ArticleEuropean journal of epidemiology2020

Risk of intellectual disability in children born appropriate-for-gestational-age at term or post-term: impact of birth weight for gestational age and gestational age.

Ruoqing Chen, Kristina Tedroff, Eduardo Villamor, Donghao Lu, Sven Cnattingius

Open access · hybridAbstract read
In one paragraph

Article in European journal of epidemiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Maternal type 1 diabetes, preterm birth, and risk of intellectual disability in the offspring: A nation-wide study in Sweden.European psychiatry : the journal of the Association of European Psychiatrists · 2024
    Article
  5. Article
  6. Article
  7. Aligning theory with practice: Child health programmes in Malaysia, a Narrative Review.Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Term Birth Weight and Neurodevelopmental Outcomes.Epidemiology (Cambridge, Mass.) · 2021
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Ruoqing ChenClinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, 171 76, Stockholm, Sweden. ruoqing.chen@ki.se.ORCID http://orcid.org/0000-0003-4911-3543
Kristina TedroffDepartment of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Eduardo VillamorDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Donghao LuDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Sven CnattingiusClinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, 171 76, Stockholm, Sweden.
Karolinska Institutet · SEBrigham and Women's Hospital · USUniversity of Michigan · US

Funding

Prenatal and Neonatal Risk Factors for Adverse Neurodevelopmental Outcomes in Childhood and Early AdulthoodR21MH120824 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI VILLAMOR, EDUARDO · 2019 to 2020
$415k
Forskningsrådet om Hälsa, Arbetsliv och Välfärd 2017-00134Karolinska Institutet 2368/10-221NIMH NIH HHS R21 MH120824NIMH NIH HHS R21MH120824
6 · The paper itself

Abstract

Children born small for gestational age have a higher risk of intellectual disability. We investigated associations of birth weight for gestational age percentile and gestational age with risk of intellectual disability in appropriate-for-gestational-age (AGA) children. We included 828,948 non-malformed term or post-term AGA singleton children (including 429,379 full siblings) born between 1998 and 2009 based on data from the Swedish Medical Birth Register. Diagnosis of intellectual disability after 3 years of age was identified through the Patient Register. Using Cox regression models, we calculated hazard ratios (HRs) with 95% confidence intervals (CIs) of intellectual disability among children with different birth weight percentiles and gestational age in the whole population and in a subpopulation of full siblings. A total of 1688 children were diagnosed with intellectual disability during follow-up. HRs (95% CIs) of intellectual disability for the low birth weight percentile groups (10th-24th and 25th-39th percentiles, respectively) versus the reference group (40th-59th percentiles) were 1.43 (1.22-1.67) and 1.28 (1.10-1.50) in population analysis and 1.52 (1.00-2.31) and 1.44 (1.00-2.09) in sibling comparison analysis. The increased risk for low birth weight percentiles in population analysis was stable irrespective of gestational age. A weak U-shaped association between gestational age and intellectual disability was observed in population analysis, although not in sibling comparison analysis. These findings suggest that among AGA children born at term or post-term, lower birth weight percentiles within the normal range are associated with increased risk of intellectual disability, regardless of gestational age.

Indexed as

Birth WeightChild, PreschoolFemaleGestational AgeHumansInfantInfant, Low Birth WeightIntellectual DisabilityMalePregnancyRisk FactorsSiblingsSwedenBirth weight for gestational ageCohort studiesGestational ageIntellectual disabilitySiblings

Identifiers

PMID31788734
PMCPMC7154017
OpenAlexW2990897438

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.