Evidence map›Paper›PMID 31788561›Full record

ArticleJournal of clinical tuberculosis and other mycobacterial diseases2019

Digital monitoring technologies could enhance tuberculosis medication adherence in Uganda: Mixed methods study.

Angella Musiimenta, Wilson Tumuhimbise, Aaron T Mugaba, Conrad Muzoora, Mari Armstrong-Hough, David Bangsberg, J Lucian Davis, Jessica E Haberer

Registry-linked trialAbstract read
In one paragraph

Article in Journal of clinical tuberculosis and other mycobacterial diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05656287 (My Mobile Wallet), which is not on this map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05656287 naunknown statusnot on this mapstarted 2022, after this paper: background citation

My Mobile Wallet: An Intervention to Support Access to Tuberculosis Care and Medication Adherence in Rural Uganda

TypeinterventionalSponsorMbarara University of Science and TechnologyRan2022 to 2026Enrolled242ConditionsTuberculosisArmsSMS texts + incentives + Wisepill device for medication monitoring, SMS texts only + Wisepill device for medication monitoring, Wisepill device for medication monitoring only
3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Angella MusiimentaMbarara University of Science and Technology, Mbarara, Uganda.
Wilson TumuhimbiseMbarara University of Science and Technology, Mbarara, Uganda.
Aaron T MugabaMbarara University of Science and Technology, Mbarara, Uganda.
Conrad MuzooraMbarara University of Science and Technology, Mbarara, Uganda.
Mari Armstrong-HoughUganda Tuberculosis Implementation Research Consortium, Makerere University, Kampala, Uganda.
David BangsbergOregon Health & Science University-Portland State University School of Public Health, USA.
J Lucian DavisUganda Tuberculosis Implementation Research Consortium, Makerere University, Kampala, Uganda.
Jessica E HabererHarvard Medical School, Boston, MA, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
TB and Other Pulmonary Complications of AIDS Research Training ProgramD43TW009607 · FIC · YALE UNIVERSITY · PI DAVIS, JOHN LUCIAN, KATAMBA, ACHILLES · 2013 to 2022
$3.2M
Optimizing mHealth for adherence monitoring and interventionK24MH114732 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI HABERER, JESSICA ELIZABETH · 2017 to 2021
$800k
Real time Tuberculosis Medication Adherence Intervention in Rural Southwestern UgandaK43TW010388 · FIC · MBARARA UNIVERSITY/SCIENCE/ TECHNOLOGY · PI MUSIIMENTA, ANGELLA · 2016 to 2021
$602k
FIC NIH HHS D43 TW009607FIC NIH HHS K43 TW010388NCATS NIH HHS UL1 TR001863NIMH NIH HHS K24 MH114732
6 · The paper itself

Abstract

backgroundEffective administration of tuberculosis therapy remains challenging. The recommended strategy of direct observed therapy is challenging and its implementation has been limited in many settings. Digital adherence technologies could be promising patient-centered strategies for monitoring adherence. However, few quality studies have assessed patients' experiences with these technologies.

objectiveTo explore TB patients' perceptions of a digital adherence intervention composed of a digital adherence monitor and SMS texts.

methodsWe purposively sampled TB patients who owned phones, had been taking TB medication for at least a month, and were receiving their treatment from Mbarara Regional Referral Hospital. We interviewed 35 TB patients to elicit information on perceptions of the proposed intervention which electronically monitors how they take their medication, and sends SMS reminders to patients to help them take their medications, as well as send SMS notifications to patients' social supporters to provide the patient with assistance if possible. We inductively analyzed data using content analysis to derive categories describing how participants perceived the intervention.

resultsParticipants anticipated that the intervention would enhance medication adherence by reminding them to take medication, and helping in the management of complicated regimen. Participants felt that monitoring adherence could enable them to demonstrate their commitment to adherence. Participants expressed concerns about not seeing the SMS on time and unintended TB status disclosure.

conclusionDigital adherence technologies may provide acceptable alternative approaches to monitoring TB medication, especially in settings where DOT is difficult to implement.

Indexed as

Digital adherence technologiesForgetfulnessHabit formationMedication adherenceReal-time monitoringSMS remindersTuberculosis

Identifiers

PMID31788561
PMCPMC6880126

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.