Evidence map›Paper›PMID 31788534›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2019

The Consortium for the early identification of Alzheimer's disease-Quebec (CIMA-Q).

Sylvie Belleville, Andréa C LeBlanc, Marie-Jeanne Kergoat, Frédéric Calon, Pierrette Gaudreau, Sébastien S Hébert, Carol Hudon, Nicole Leclerc, Naguib Mechawar, Simon Duchesne and 2 more

Open access · goldAbstract read
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Plasma p-tau markers, vascular factors, and cognitive decline in the CIMA-Q cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
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  4. Differences in blood levels of neuroligin-derived peptides in a cohort for early detection of Alzheimer's disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
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  14. A quadratic function of activation in individuals at risk of Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 10 institutions in 1 country.

Sylvie BellevillePsychology Department, Université de Montréal, Montreal, Canada.
Andréa C LeBlancDepartment of Neurology and Neurosurgery, McGill University, Montreal, Canada.
Marie-Jeanne KergoatResearch Center, Institut Universitaire de Gériatrie de Montréal, Montreal, Canada.
Frédéric CalonFaculty of Pharmacy, Université Laval, Québec, Canada.
Pierrette GaudreauDepartment of Medicine, Université de Montréal, Montreal, Canada.
Sébastien S HébertCentre de recherche du CHU de Québec, Université Laval, Québec, Canada.
Carol HudonSchool of Psychology, Université Laval, Québec, Canada.
Nicole LeclercCentre Hospitalier de l'Université de Montréal Research Center, Montreal, Canada.
Naguib MechawarDepartment of Psychiatry, McGill University, Montreal, Canada.
Simon DuchesneCentre de recherche CERVO, Institut Universitaire en Santé Mentale de Québec, Quebec, Canada.
Serge GauthierDepartment of Psychiatry, McGill University, Montreal, Canada.
Consortium for the Early Identification of Alzheimer's disease-Quebec (CIMA-Q)
Université de Montréal · CAMcGill University · CAInstitut Universitaire de Gériatrie de Montréal · CACentre Hospitalier de l’Université de Montréal · CAJewish General Hospital · CADouglas Mental Health University Institute · CAInstitut Universitaire en Santé Mentale de Québec · CACentre hospitalier de l'Université Laval · CAUniversité du Québec à Montréal · CAUniversité Laval · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe Consortium for the early identification of Alzheimer's disease-Quebec (CIMA-Q) created a research infrastructure to recruit, characterize, and track disease progression in individuals at risk of dementia.

methodsCIMA-Q established standardized clinical, neuropsychological, neuroimaging, blood (plasma, serum, RNA, genomic DNA), cryopreserved peripheral blood mononuclear cells, and cerebrospinal fluid collection protocols. These data and biological materials are available to the research community.

resultsIn phase 1, 115 persons with subjective cognitive decline, 88 with mild cognitive impairment, 31 with early probable Alzheimer's disease, and 56 older adults with no worries nor impairments received detailed clinical and cognitive evaluations as well as blood and peripheral blood mononuclear cells collections. Among them, 142 underwent magnetic resonance imaging, 29 a DISCUSSION: CIMA-Q provides procedures and resources to identify early biomarkers and novel therapeutic targets, and holds promise for detecting cognitive decline in Alzheimer's disease.

Indexed as

Alzheimer's diseaseBiomarkerCIMA-QClinical cohortConsortium for the early identification of Alzheimer's disease-QuebecCryopreserved PBMNCEarly diagnosisMild cognitive impairmentSubjective cognitive decline

Identifiers

PMID31788534
PMCPMC6880140
OpenAlexW2990177721

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.