ArticleAdvances in motivation science2019
Motivation in the Service of Allostasis: The Role of anterior Mid Cingulate Cortex.
Article in Advances in motivation science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Distinct patterns of prefrontal cortical disengagement during inhibitory control in addiction: A meta-analysis based on population characteristics.Neuroscience and biobehavioral reviews · 2021Pooled it
- Metformin improves cognitive impairment in patients with schizophrenia: associated with enhanced functional connectivity of dorsolateral prefrontal cortex.Translational psychiatry · 2023Trial
- Focused Ultrasound Neuromodulation of Salience Network Hubs Selectively Enhances Anxiety-Relevant Autonomic Habituation in Humans.Biological psychiatry global open science · 2026Article
- Dynamic emotion fabric theory: a new framework for understanding the biology of flexible emotion states.Social cognitive and affective neuroscience · 2026Review
- Apathy and Reduced Voluntary Activity in Older Adults with Parkinson's Disease: Mechanisms, Clinical Assessment, and Rehabilitation Implications.Clinical interventions in aging · 2026Review
- Primary Appraisal is Affective not Cognitive: Exploring a Revised Transactional Model of Stress and Coping.Applied psychophysiology and biofeedback · 2025Article
- Cognitive effort devaluation and the salience network: a computational model of amotivation in depression.Frontiers in psychiatry · 2025Article
- Dissecting abstract, modality-specific and experience-dependent coding of affect in the human brain.Science advances · 2024Article
- Laminar dynamics of deep projection neurons and mode of subplate formation are hallmarks of histogenetic subdivisions of the human cingulate cortex before onset of arealization.Brain structure & function · 2023Article
- A Matter of Taste: Roles of Taste Preference on Performance and Psychological Responses during Anaerobic Exercise.International journal of environmental research and public health · 2023Article
- Pubertal development underlies optimization of inhibitory control through specialization of ventrolateral prefrontal cortex.Developmental cognitive neuroscience · 2022Article
- Effortless training of attention and self-control: mechanisms and applications.Trends in cognitive sciences · 2022Review
- Brain, behavioral, affective, and sex correlates of recovery from alcohol use disorders.Alcoholism, clinical and experimental research · 2021Article
- The thermodynamic brain and the evolution of intellect: the role of mental energy.Cognitive neurodynamics · 2020Review
- Affect in the Aging Brain: A Neuroimaging Meta-Analysis of Older Vs. Younger Adult Affective Experience and Perception.Affective science · 2020Article
- The Differences Between Individuals Engaging in Nonsuicidal Self-Injury and Suicide Attempt Are Complex (Frontiers in psychiatry · 2020Article
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Authors and funding
5 authors.
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Abstract
In this article, we suggest that motivation serves to anticipate the energy of the body and meet those needs before they arise, called allostasis. We describe motivation as the output of energy computations that include estimates about future energy/metabolic needs and the value of effort required for potential behaviors (i.e., whether the cost of effort is worthwhile). We bring neuroscience evidence to bear to support this hypothesis. We outline a system of brain networks that have been shown to be important for motivation, and focus in on one hub in this network, the anterior mid-cingulate cortex (aMCC), and discuss its importance for establishing motivation in the service of allostasis. We present evidence that the aMCC, positioned at the intersection of multiple brain networks, is wired to integrate signals relating to allostasis with its sensory consequences, termed interoception, as well as with cognitive control processes, sensory and motor functions. This integration guides the nervous system towards the optimal effort required to achieve a desired goal. Across a variety of task domains, we discuss the role of aMCC in motivation, including a) processing of the value of prior and expected rewards, b) assessment of energetic costs in the brain and the body, c) selectively learning and encoding prediction errors (unexpected changes) that are relevant for allostasis, d) computations for monitoring of internal states of the body and e) modulating the internal state of the body to prepare for action. Finally, we discuss the link between individual differences in aMCC processing and variation in two extreme ends of the range of motivational states, tenacity and apathy.
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