ArticleTranslational vision science & technology2019
Objective Measurement of Local Rod and Cone Function Using Gaze-Controlled Chromatic Pupil Campimetry in Healthy Subjects.
Article in Translational vision science & technology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Safety and vision outcomes of subretinal gene supplementation therapy inThe British journal of ophthalmology · 2026Trial
- Model-based comparison of latency estimation methods for the pupillary light reflex.Scientific reports · 2026Article
- Mild RPE65-Associated Inherited Retinal Dystrophies: A Multimodal Clinical and Genetic Evaluation.Translational vision science & technology · 2025Article
- Chromatic pupil campimetry as objective diagnostic tool for progressive optic neuropathies.Documenta ophthalmologica. Advances in ophthalmology · 2025Article
- Optimizing latency calculation for robust evaluation of the pupillary light response in chromatic pupillography.Documenta ophthalmologica. Advances in ophthalmology · 2025Article
- Deep Learning-Based Retinal Layer Segmentation in Optical Coherence Tomography Scans of Patients with Inherited Retinal Diseases.Klinische Monatsblatter fur Augenheilkunde · 2025Article
- Uncovering the Characteristics of Pupil Cycle Time (PCT) in Neuropathies and Retinopathies.Vision (Basel, Switzerland) · 2025Article
- Influencing Factors on Pupillary Light Responses as a Biomarker for Local Retinal Function in a Large Normative Cohort.Investigative ophthalmology & visual science · 2024Article
- Multi-luminance mobility testing after gene therapy in the context of retinal functional diagnostics.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Establishing Fully-Automated Fundus-Controlled Dark Adaptometry: A Validation and Retest-Reliability Study.Translational vision science & technology · 2023Article
- Rod and Cone Function Measured Objectively by Chromatic Pupil Campimetry Show a Different Preservation Between Distinct Genotypes in Retinitis Pigmentosa.Investigative ophthalmology & visual science · 2023Article
- Central retina plays a decisive role in the suppression of pupillary escape.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Article
- The Trade-Off Between Luminance and Color Contrast Assessed With Pupil Responses.Translational vision science & technology · 2023Article
- Effects of Stimulus Luminance, Stimulus Color and Intra-Stimulus Color Contrast on Visual Field Mapping in Neurologically Impaired Adults Using Flicker Pupil Perimetry.Eye and brain · 2023Article
- Spatial and temporal resolution of the photoreceptors rescue dynamics after treatment with voretigene neparvovec.The British journal of ophthalmology · 2022Article
- How lesions at different locations along the visual pathway influence pupillary reactions to chromatic stimuli.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Article
- Effect of central and peripheral cone- and rod-specific stimulation on the pupillary light reflex.International ophthalmology · 2022Article
- Evaluation of Local Rod and Cone Function in Stargardt Disease.Investigative ophthalmology & visual science · 2022Article
- Maintaining fixation by children in a virtual reality version of pupil perimetry.Journal of eye movement research · 2022Article
- "Blue Sky Effect": Contextual Influences on Pupil Size During Naturalistic Visual Search.Frontiers in psychology · 2021Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe introduce a new approach for functional mapping of rod and cone activity by measuring pupillary responses to local stimulation via gaze-controlled chromatic pupil campimetry (CPC).
methodsPupillary constriction amplitude and latency to constriction onset to local photopic and scotopic light stimuli at different locations within the 30° central visual field were analyzed in 14 healthy subjects (4 males, 34 ± 11 years, mean ± standard deviation [SD]). All subjects were measured twice for evaluating the test-retest variability and reproducibility of the method.
resultsFor the cone-favoring protocol (ConeProt), the relative maximal constriction amplitude was most pronounced in the center (26.8% ± 6.3%) with a hill-shaped decrease from the fovea to the periphery. For the rod-favoring protocol (RodProt), it was smaller (center, 13.5% ± 4.5%) with a profile lacking the central peak. Mean latency to constriction onset was faster for cones (277 ± 25 ms) than for rods (372 ± 13 ms). Mean intraclass correlation at the different stimulus locations was 0.84 ± 0.08 for RodProt and 0.75 ± 0.11 for ConeProt; mean coefficients of repeatability value of all stimulus locations was 5.9% ± 1.2% and 8.6% ± 1.7%, respectively.
conclusionsCPC provides an objective evaluation of local rod and cone function within the central 30° visual field. It shows a photoreceptor-specific profile in healthy subjects. Due to its easy, noncontact, gaze-controlled character, it is a clinically applicable method and may fill the gap of functional diagnostics of rods and cones of the human retina. TRANSLATIONAL RELEVANCE: Chromatic pupil campimetry provides information about the local rod and cone function of the human retina with distinct pattern of distributions in an objective manner.
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