ArticleOncology letters2019
Mitotically-associated long non-coding RNA promotes cancer cell proliferation in hepatocellular carcinoma by downregulating miR-122a.
Article in Oncology letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- LncRNA LINC00704 drives cancer stemness and malignant properties in oral squamous cell carcinomas by sponging miR-204.Journal of dental sciences · 2025Article
- Bromodomain Proteins Epigenetically Regulate the Mitotically Associated lncRNA MANCR in Triple Negative Breast Cancer Cells.Critical reviews in eukaryotic gene expression · 2024Article
- MANCR lncRNA Modulates Cell-Cycle Progression and Metastasis by Cis-Regulation of NuclearMolecular and cellular biology · 2024Article
- The Expression Patterns and Implications ofInternational journal of molecular sciences · 2023Article
- Systematic Analysis of Long Non-Coding RNA Genes in Nonalcoholic Fatty Liver Disease.Non-coding RNA · 2022Article
- Relief Effects of Icariin on Inflammation-Induced Decrease of Tight Junctions in Intestinal Epithelial Cells.Frontiers in pharmacology · 2022Article
- Long-Noncoding RNA MANCR is Associated With Head and Neck Squamous Cell Carcinoma Malignant Development and Immune Infiltration.Frontiers in genetics · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitotically-associated long non-coding RNA (MANCR) is involved in malignant breast cancer. The present study analyzed the role of MANCR in hepatocellular carcinoma (HCC). MANCR was found to be upregulated in HCC and high expression level of MANCR in cancer tissues predicted poor survival of HCC patients. MicroRNA (miR)-122a was downregulated HCC and was inversely correlated with MANCR only in cancer tissues. MANCR overexpression resulted in downregulation of miR-122a, while miR-122a overexpression showed no obvious effects on MANCR expression. MANCR overexpression showed no significant effects on HCC cell proliferation but led to promoted cell migration and invasion. miR-122a overexpression led to inhibited migration and invasion of HCC cells and attenuated the effects of MANCR overexpression. Therefore, lncRNA MANCR may promote cancer cell proliferation in HCC by downregulating miR-122a.
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