Evidence map›Paper›PMID 31787962›Full record

ArticleFrontiers in microbiology2019

RAFT-Derived Polymethacrylates as a Superior Treatment for Recurrent Vulvovaginal Candidiasis by Targeting Biotic Biofilms and Persister Cells.

Xueqing Wu, Sisi Zhang, Xinxin Xu, Laien Shen, Boyun Xu, Wenzhen Qu, Wenyi Zhuang, Katherine Locock, Margaret Deighton, Yue Qu

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Biofilm · 2023
    Article
  6. Article
  7. Review
  8. New perspectives on the topical management of recurrent candidiasis.Drug delivery and translational research · 2021
    Review
  9. Frontiers in cellular and infection microbiology · 2021
    Article
  10. Biofilm Formation ofFrontiers in microbiology · 2020
    Article
  11. Frontiers in microbiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Xueqing WuThe Division of Gynecology, Shenzhen University General Hospital, Shenzhen, China.
Sisi ZhangDepartment of Obstetrics and Gynecology, Wenzhou Medical University, Wenzhou, China.
Xinxin XuDepartment of Obstetrics and Gynecology, Wenzhou Medical University, Wenzhou, China.
Laien ShenDepartment of Obstetrics and Gynecology, Wenzhou Medical University, Wenzhou, China.
Boyun XuDepartment of Obstetrics and Gynecology, Wenzhou Medical University, Wenzhou, China.
Wenzhen QuDepartment of Obstetrics and Gynecology, Wenzhou Medical University, Wenzhou, China.
Wenyi ZhuangThe Division of Gynecology, Shenzhen University General Hospital, Shenzhen, China.
Katherine LocockCSIRO Manufacturing Flagship, Clayton, VIC, Australia.
Margaret DeightonSchool of Applied Sciences, RMIT University, Bundoora, VIC, Australia.
Yue QuNeonatal Intensive Care Unit, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Wenzhou Medical University · CNCSIRO Manufacturing · AURMIT University · AUSecond Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University · CNShenzhen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVulvovaginal candidiasis (VVC) is a common infection in need of more effective treatment. Formation of epithelium-associated

methodsA mouse model of VVC was used to establish vaginal epithelium-associated biofilms, using

resultsPolymethacrylates showed negligible local toxicity, resistance to vaginal acidity, and outstanding

conclusionThis study systematically assessed the clinical potential of RAFT-derived polymethacrylates as an effective treatment for VVC/RVVC in a mouse model. Polymethacrylates effectively killed vaginal epithelium-related

Indexed as

antifungal treatmentbiotic biofilmsmouse modelpersister cellspopulation analysisRAFT-derived polymethacrylatesRVVC

Identifiers

PMID31787962
PMCPMC6853869
OpenAlexW2983141982

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.