ReviewFrontiers in endocrinology2019
Hypercortisolemia Recurrence in Cushing's Disease; a Diagnostic Challenge.
Review in Frontiers in endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 45 citations in OpenAlex.
- Trial
- Effects of Time-Restricted Eating on Circadian Cortisol Secretion and Obesity-Related Metabolic Markers in Cushing's Disease: A Pilot Study.Nutrients · 2026Article
- Patients with Cushing's syndrome suffer from provoked venous thromboembolism and are anticoagulated in various patterns.Endocrine connections · 2024Article
- Recognition of Nonneoplastic Hypercortisolism in the Evaluation of Patients With Cushing Syndrome.Journal of the Endocrine Society · 2023Article
- Article
- Article
- Utility of a corticotropin-releasing hormone test to differentiate pituitary-dependent hyperadrenocorticism from cortisol-producing adrenal tumors in dogs.Journal of veterinary internal medicine · 2022Article
- Consensus on diagnosis and management of Cushing's disease: a guideline update.The lancet. Diabetes & endocrinology · 2021Review
- Signs, symptoms and biochemistry in recurrent Cushing disease: a prospective pilot study.Endocrine · 2021Article
- Cyclic Cushing's Syndrome - A Diagnostic Challenge.Frontiers in endocrinology · 2021Review
- Prospective Evaluation of Late-Night Salivary Cortisol and Cortisone by EIA and LC-MS/MS in Suspected Cushing Syndrome.Journal of the Endocrine Society · 2020Article
- Salivary Cortisol in the Diagnosis of Cushing Syndrome, Always More Than One!Journal of the Endocrine Society · 2020Review
- Efficacy and Safety of Levoketoconazole in Managing Cushing's Syndrome: A Systematic Review.Indian journal of endocrinology and metabolismReview
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cushing's disease recurrence following successful pituitary surgery is common and merits prompt and careful diagnosis, as untreated hypercortisolism leads to increased morbidity and mortality. However, an established recurrence definition has not been forthcoming. This poses a diagnostic challenge especially early in the course of returning hypercortisolemia and/or in the presence of non-neoplastic hypercortisolemia. A late-night salivary cortisol (LNSC) test is the first test to reveal abnormal results, however, has limitations related to assay performance as well as individual patient variability. Dexamethasone suppression tests and 24-h urinary free cortisol (UFC) results are next to reveal abnormal results. Other tests including, corticotropin-releasing hormone (CRH) stimulation test and combined CRH-dexamethasone test, as well as desmopressin stimulation test with/without dexamethasone are also used, although, none have proven to be the preeminent diagnostic test for recurrence determination. There is a possible role for these tests in predicting recurrence in patients who have experienced remission, though, this also remains challenging due to lack of established cutoff values. This article details and summarizes evidence about different diagnostic tests currently used to diagnose and predict Cushing's disease recurrence.
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