ArticleMacromolecules2019
Langevin Dynamics Simulations of the Exchange of Complex Coacervate Core Micelles: The Role of Nonelectrostatic Attraction and Polyelectrolyte Length.
Article in Macromolecules, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Microstructural Rearrangements in Triblock Polyelectrolyte Complex Hydrogels.ACS macro letters · 2025Article
- Effect of Charged Block Length Mismatch on Double Diblock Polyelectrolyte Complex Micelle Cores.Macromolecules · 2023Article
- Article
- DNA dynamics in complex coacervate droplets and micelles.Soft matter · 2022Article
- Responsive Pickering Emulsions Stabilized by Frozen Complex Coacervate Core Micelles.ACS macro letters · 2022Article
- Advances in the Structural Design of Polyelectrolyte Complex Micelles.The journal of physical chemistry. B · 2021Article
- FRET-Based Determination of the Exchange Dynamics of Complex Coacervate Core Micelles.Macromolecules · 2021Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Complex coacervate core micelles (C3Ms) are promising encapsulators for a wide variety of (bio)molecules. To protect and stabilize their cargo, it is essential to control their exchange dynamics. Yet, to date, little is known about the kinetic stability of C3Ms and the dynamic equilibrium of molecular building blocks with micellar species. Here we study the C3M exchange during the initial micellization by using Langevin dynamics simulations. In this way, we show that charge neutral heterocomplexes consisting of multiple building blocks are the primary mediator for exchange. In addition, we show that the kinetic stability of the C3Ms can be tuned not only by the electrostatic interaction but also by the nonelectrostatic attraction between the polyelectrolytes, the polyelectrolyte length ratio, and the overall polyelectrolyte length. These insights offer new rational design guides to aid the development of new C3M encapsulation strategies.
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Registered trials
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