Evidence map›Paper›PMID 31787434›Full record

ArticleJournal of cardiothoracic and vascular anesthesia2020

Epiaortic Ultrasound for Assessment of Intraluminal Atheroma; Insights from the REGROUP Trial.

Alexander D Shapeton, Kay B Leissner, Suzana M Zorca, Houman Amirfarzan, Eileen M Stock, Kousick Biswas, Miguel Haime, Venkatesh Srinivasa, Jacquelyn A Quin, Marco A Zenati

2 registry-linked trialsOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiothoracic and vascular anesthesia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01850082 nacompletednot on this map

CSP #588 - Randomized Endo-Vein Graft Prospective (REGROUP) Trial

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2013 to 2020Enrolled1,150ConditionsCoronary Artery Bypass GraftingArmsVein Harvesting Procedures
NCT07101393 completednot on this mapstarted 2023, after this paper: background citation

Determination of Postoperative Stroke Incidence in Patients With and Without the Use of Epiaortic Ultrasound in Coronary Artery Bypass Grafting Surgery

TypeobservationalSponsorAtaturk UniversityRan2023 to 2025Enrolled150ConditionsPostoperative Delirium, Postoperative StrokeArmsIntraoperative Epiaortic Ultrasound (EAU)
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Alexander D ShapetonCooperative Studies Program Coordinating Center, Office of Research and Development, Department of Veterans Affairs, Perry Point, MD. Electronic address: alexander.shapeton@va.gov.
Kay B LeissnerCooperative Studies Program Coordinating Center, Office of Research and Development, Department of Veterans Affairs, Perry Point, MD.
Suzana M ZorcaCooperative Studies Program Coordinating Center, Office of Research and Development, Department of Veterans Affairs, Perry Point, MD.
Houman AmirfarzanCooperative Studies Program Coordinating Center, Office of Research and Development, Department of Veterans Affairs, Perry Point, MD.
Eileen M StockCooperative Studies Program Coordinating Center, Office of Research and Development, Department of Veterans Affairs, Perry Point, MD.
Kousick BiswasCooperative Studies Program Coordinating Center, Office of Research and Development, Department of Veterans Affairs, Perry Point, MD.
Miguel HaimeDivision of Cardiac Surgery, Veterans Affairs Boston Healthcare System and Harvard Medical School, Boston, MA.
Venkatesh SrinivasaDepartment of Anesthesia, Critical Care and Pain Medicine, Veterans Affairs Boston Healthcare System and Harvard Medical School, Boston, MA.
Jacquelyn A QuinDivision of Cardiac Surgery, Veterans Affairs Boston Healthcare System and Harvard Medical School, Boston, MA.
Marco A ZenatiDivision of Cardiac Surgery, Veterans Affairs Boston Healthcare System and Harvard Medical School, Boston, MA.
VA Boston Healthcare System · US

Funding

CSP VA 588
6 · The paper itself

Abstract

objectivesTo assess the use of epiaortic ultrasound in contemporary cardiac surgery, as well as its impact on surgical cannulation strategy and cerebrovascular events.

designEpiaortic ultrasound data was prospectively collected in the Randomized Endovein Graft Prospective (REGROUP) trial (VA Cooperative Studies Program #588, ClinicalTrials.gov, NCT01850082), which randomized 1,150 coronary artery bypass graft patients between 2014 and 2017 to endoscopic or open-vein graft harvest.

settingSixteen cardiac surgery programs within the Veterans Affairs Healthcare System with expertise at performing endoscopic vein-graft harvesting.

participantsVeterans Affairs patients, greater than 18 years of age, undergoing elective or urgent coronary artery bypass grafting with cardiopulmonary bypass and cardioplegic arrest with at least one planned saphenous vein graft were eligible for enrollment.

interventionsEpiaortic ultrasound was performed by the surgeon using a high frequency (>7 MHz) ultrasound transducer. Two-dimensional images of the ascending aorta in multiple planes were acquired before aortic cannulation and cross-clamping. MEASUREMENTS AND MAIN

resultsEpiaortic ultrasound was performed in 34.1% (269 of 790) of patients in REGROUP. Among these patients, simple intraluminal atheroma was observed in 21.9% (59 269), and complex intraluminal atheroma comprised 2.2% (6 of 269). The aortic cannulation or cross-clamp strategy was modified based on these findings in 7.1% of cases (19 of 269). There was no difference in stroke between patients who underwent epiaortic ultrasound and those who did not (1.9% v 1.2% p = 0.523).

conclusionsDespite current guidelines recommending routine use of epiaortic ultrasound (IIa/B) to reduce the risk of stroke in cardiac surgery, in this contemporary trial, use remains infrequent, with significant site-to-site variability.

Indexed as

Aortic DiseasesPlaque, AtheroscleroticAortaCoronary Artery BypassHumansProspective Studiesascending aortacoronary artery bypass graftingechocardiography, transesophagealplaque, atheroscleroticstrokeultrasonography

Identifiers

PMID31787434
PMCPMC7243360
OpenAlexW2987886893

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.