Evidence map›Paper›PMID 31787049›Full record

ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2020

Pronounced somatic bottleneck in mitochondrial DNA of human hair.

Alison Barrett, Barbara Arbeithuber, Arslan Zaidi, Peter Wilton, Ian M Paul, Rasmus Nielsen, Kateryna D Makova

Open access · hybridAbstract read
In one paragraph

Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 37 citations in OpenAlex.

  1. Mitochondria in focus: From structure and function to their role in human diseases. A review.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2025
    Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Precision mitochondrial medicine.Cambridge prisms. Precision medicine · 2023
    Review
  8. Advanced age increases frequencies of de novo mitochondrial mutations in macaque oocytes and somatic tissues.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  9. Article
  10. Cellular mechanisms of mtDNA heteroplasmy dynamics.Critical reviews in biochemistry and molecular biology · 2021
    Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Linking the mitochondrial genotype to phenotype: a complex endeavour.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Alison BarrettDepartment of Biology, Penn State University, University Park, PA, USA.
Barbara ArbeithuberDepartment of Biology, Penn State University, University Park, PA, USA.
Arslan ZaidiDepartment of Biology, Penn State University, University Park, PA, USA.
Peter WiltonDepartment of Integrative Biology, University of California at Berkeley, Berkeley, CA, USA.
Ian M PaulDepartment of Pediatrics, Penn State College of Medicine, Hershey, PA, USA.
Rasmus NielsenDepartment of Integrative Biology, University of California at Berkeley, Berkeley, CA, USA.
Kateryna D MakovaDepartment of Biology, Penn State University, University Park, PA, USA.
Pennsylvania State University · USUniversity of California, Berkeley · USPenn State Milton S. Hershey Medical Center · US

Funding

The Dynamics of Mitochondrial MutationsR01GM116044 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI MAKOVA, KATERYNA, NIELSEN, RASMUS · 2015 to 2018
$2.4M
NIGMS NIH HHS R01 GM116044
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Gene FrequencyAdolescentAdultAgedDNA, MitochondrialHairHigh-Throughput Nucleotide SequencingHumansMiddle AgedPennsylvaniaYoung AdultDNA, Mitochondrialforensicshair developmentheteroplasmymitochondrionmtDNAsomatic bottleneck

Identifiers

PMID31787049
PMCPMC6939377
OpenAlexW2989686948

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.