ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2020
Linking the mitochondrial genotype to phenotype: a complex endeavour.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
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- Changes in life history and morphological traits over 8 generations in the brown marmorated stink bug (Hemiptera: Pentatomidae) under mass-rearing conditions.Journal of insect science (Online) · 2025Article
- High heteroplasmy is associated with low mitochondrial copy number and selection against non-synonymous mutations in the snail Cepaea nemoralis.BMC genomics · 2024Article
- Sequencing of the Complete Mitochondrial Genome of the Big Brown Mactra Clam,Animals : an open access journal from MDPI · 2024Article
- Adaptive advantages of restorative RNA editing in fungi for resolving survival-reproduction trade-offs.Science advances · 2024Article
- Mice selected for a high basal metabolic rate evolved larger guts but not more efficient mitochondria.Proceedings. Biological sciences · 2022Article
- Role of Genes in Regulating Host Plants Expansion in Tephritid Fruit Flies (Diptera) and Potential for RNAi-Based Control.Journal of insect science (Online) · 2022Review
- Inheritance through the cytoplasm.Heredity · 2022Review
- Parents exposed to warming produce offspring lower in weight and condition.Ecology and evolution · 2022Article
- Biodiversity and Distribution ofInsects · 2022Article
- Contrasting modes of mitochondrial genome evolution in sister taxa of wood-eating marine bivalves (Teredinidae and Xylophagaidae).Genome biology and evolution · 2022Article
- The mitochondrial DNA constitution shaping T-cell immunity in patients with rectal cancer at high risk of metastatic progression.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022Article
- Mitochondrial Short-Term Plastic Responses and Long-Term Evolutionary Dynamics in Animal Species.Genome biology and evolution · 2021Review
- A Naturally Heteroplasmic Clam Provides Clues about the Effects of Genetic Bottleneck on Paternal mtDNA.Genome biology and evolution · 2021Article
- Mitochondrial-Y chromosome epistasis inProceedings. Biological sciences · 2020Article
- Mitochondrial-nuclear coadaptation revealed through mtDNA replacements in Saccharomyces cerevisiae.BMC evolutionary biology · 2020Article
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Finding causal links between genotype and phenotype is a major issue in biology, even more in mitochondrial biology. First of all, mitochondria form complex networks, undergoing fission and fusion and we do not know how such dynamics influence the distribution of mtDNA variants across the mitochondrial network and how they affect the phenotype. Second, the non-Mendelian inheritance of mitochondrial genes can have sex-specific effects and the mechanism of mitochondrial inheritance is still poorly understood, so it is not clear how selection and/or drift act on mtDNA genetic variation in each generation. Third, we still do not know how mtDNA expression is regulated; there is growing evidence for a convoluted mechanism that includes RNA editing, mRNA stability/turnover, post-transcriptional and post-translational modifications. Fourth, mitochondrial activity differs across species as a result of several interacting processes such as drift, adaptation, genotype-by-environment interactions, mitonuclear coevolution and epistasis. This issue will cover several aspects of mitochondrial biology along the path from genotype to phenotype, and it is subdivided into four sections focusing on mitochondrial genetic variation, on the relationship among mitochondria, germ line and sex, on the role of mitochondria in adaptation and phenotypic plasticity, and on some future perspectives in mitochondrial research. This article is part of the theme issue 'Linking the mitochondrial genotype to phenotype: a complex endeavour'.
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