ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2020
Linking paternally inherited mtDNA variants and sperm performance.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 30 citations in OpenAlex.
- Small-scale habitat heterogeneity and genotype modulate in situ gene expression of the Antarctic bivalve Aequiyoldia eightsii in front of a melting glacier.BMC ecology and evolution · 2025Article
- Silent cells? Potential for context-dependent gene expression in mature sperm.Proceedings. Biological sciences · 2025Review
- Mitonuclear compatibility is maintained despite relaxed selection on male mitochondrial DNA in bivalves with doubly uniparental inheritance.Evolution; international journal of organic evolution · 2024Article
- The absence of canonical respiratory complex I subunits in male-type mitogenomes of three Donax species.Scientific reports · 2024Article
- An evolving roadmap: using mitochondrial physiology to help guide conservation efforts.Conservation physiology · 2024Article
- Mitonuclear Sex Determination? Empirical Evidence from Bivalves.Molecular biology and evolution · 2023Article
- Female reproductive fluids 'rescue' sperm from phenotypic ageing in an external fertilizer.Proceedings. Biological sciences · 2023Article
- A tale of two paths: The evolution of mitochondrial recombination in bivalves with doubly uniparental inheritance.The Journal of heredity · 2023Article
- The longest mitochondrial protein in metazoans is encoded by the male-transmitted mitogenome of the bivalveBiology letters · 2022Article
- Lack of transcriptional coordination between mitochondrial and nuclear oxidative phosphorylation genes in the presence of two divergent mitochondrial genomes.Zoological research · 2022Article
- Relaxed selection on male mitochondrial genes in DUI bivalves eases the need for mitonuclear coevolution.Journal of evolutionary biology · 2021Article
- Bioenergetic consequences of sex-specific mitochondrial DNA evolution.Proceedings. Biological sciences · 2021Article
- Molluscan mitochondrial genomes break the rules.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- A Naturally Heteroplasmic Clam Provides Clues about the Effects of Genetic Bottleneck on Paternal mtDNA.Genome biology and evolution · 2021Article
- The role of oxidative stress in postcopulatory selection.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Post-ejaculation thermal stress causes changes to the RNA profile of sperm in an external fertilizer.Proceedings. Biological sciences · 2020Article
- Faraway, so close. The comparative method and the potential of non-model animals in mitochondrial research.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Linking the mitochondrial genotype to phenotype: a complex endeavour.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Providing robust links between mitochondrial genotype and phenotype is of major importance given that mitochondrial DNA (mtDNA) variants can affect reproductive success. Because of the strict maternal inheritance (SMI) of mitochondria in animals, haplotypes that negatively affect male fertility can become fixed in populations. This phenomenon is known as 'mother's curse'. Doubly uniparental inheritance (DUI) of mitochondria is a stable exception in bivalves, which entails two mtDNA lineages that evolve independently and are transmitted separately through oocytes and sperm. This makes the DUI mitochondrial lineages subject to different sex-specific selective sieves during mtDNA evolution, thus DUI is a unique model to evaluate how direct selection on sperm mitochondria could contribute to male reproductive fitness. In this study, we tested the impact of mtDNA variants on sperm performance and bioenergetics in DUI and SMI species. Analyses also involved measures of sperm performance following inhibition of main energy pathways and sperm response to oocyte presence. Compared to SMI, DUI sperm exhibited (i) low speed and linearity, (ii) a strict OXPHOS-dependent strategy of energy production, and (iii) a partial metabolic shift towards fermentation following egg detection. Discussion embraces the adaptive value of mtDNA variation and suggests a link between male-energetic adaptation, fertilization success and paternal mitochondria preservation. This article is part of the theme issue 'Linking the mitochondrial genotype to phenotype: a complex endeavour'.
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