ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2020
Mitonuclear conflict and cooperation govern the integration of genotypes, phenotypes and environments.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Mito-nuclear incompatibility disrupts acyl-CoA oxidase 1/acyl-CoA oxidase 3-mediated mitochondria-peroxisome metabolic coordination in black soldier flies.Molecular biology and evolution · 2026Article
- Mitochondrial Transfer: From Bench to Bedside.Circulation research · 2026Review
- Hybridization and gene expression: Beyond differentially expressed genes.Molecular ecology · 2025Review
- Evolution and maintenance of mtDNA gene content across eukaryotes.The Biochemical journal · 2024Review
- The role of mitochondria in sex- and age-specific gene expression in a species without sex chromosomes.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Mother's Curse effects on lifespan and aging.Frontiers in aging · 2024Review
- The role of mitochondria in sex- and age-specific gene expression in a species without sex chromosomes.bioRxiv : the preprint server for biology · 2023Article
- Mitonuclear interactions shape both direct and parental effects of diet on fitness and involve a SNP in mitoribosomal 16s rRNA.PLoS biology · 2023Article
- Evolutionary codependency: insights into the mitonuclear interaction landscape from experimental and wild Caenorhabditis nematodes.Current opinion in genetics & development · 2023Review
- Mitonuclear Interactions and the Origin of Macaque Societies.Genome biology and evolution · 2023Article
- G × G × E effect on phenotype expression in a non-conventional model organism, the unicellular slime mouldBiology letters · 2023Article
- Mitochondrial effects on fertility and longevity inProceedings. Biological sciences · 2022Article
- Investigating the Impact of a Curse: Diseases, Population Isolation, Evolution and the Mother's Curse.Genes · 2022Review
- Inheritance through the cytoplasm.Heredity · 2022Review
- Mitochondria as environments for the nuclear genome in Drosophila: mitonuclear G×G×E.The Journal of heredity · 2022Article
- Human genetic analyses of organelles highlight the nucleus in age-related trait heritability.eLife · 2021Article
- A photosynthesis operon in the chloroplast genome drives speciation in evening primroses.The Plant cell · 2021Article
- Mitochondrial Short-Term Plastic Responses and Long-Term Evolutionary Dynamics in Animal Species.Genome biology and evolution · 2021Review
- Evidence for a Syncytial Origin of Eukaryotes from Ancestral State Reconstruction.Genome biology and evolution · 2021Article
- Mother's curse is pervasive across a large mitonuclearEvolution letters · 2021Article
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Abstract
The mitonuclear genome is the most successful co-evolved mutualism in the history of life on Earth. The cross-talk between the mitochondrial and nuclear genomes has been shaped by conflict and cooperation for more than 1.5 billion years, yet this system has adapted to countless genomic reorganizations by each partner, and done so under changing environments that have placed dramatic biochemical and physiological pressures on evolving lineages. From putative anaerobic origins, mitochondria emerged as the defining aerobic organelle. During this transition, the two genomes resolved rules for sex determination and transmission that made uniparental inheritance the dominant, but not a universal pattern. Mitochondria are much more than energy-producing organelles and play crucial roles in nutrient and stress signalling that can alter how nuclear genes are expressed as phenotypes. All of these interactions are examples of genotype-by-environment (GxE) interactions, gene-by-gene (GxG) interactions (epistasis) or more generally context-dependent effects on the link between genotype and phenotype. We provide evidence from our own studies in
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