Evidence map›Paper›PMID 31786979›Full record

ArticleHypertension (Dallas, Tex. : 1979)2020

Ang II (Angiotensin II) Conversion to Angiotensin-(1-7) in the Circulation Is POP (Prolyloligopeptidase)-Dependent and ACE2 (Angiotensin-Converting Enzyme 2)-Independent.

Peter Serfozo, Jan Wysocki, Gvantca Gulua, Arndt Schulze, Minghao Ye, Pan Liu, Jing Jin, Michael Bader, Timo Myöhänen, J Arturo García-Horsman and 1 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04705766 (The KIDCOV Study), which is not on this map. Cited by 123 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed, 1 pooled it
22.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04705766 recruitingnot on this mapstarted 2021, after this paper: background citation

The KIDCOV Study: ASSESSMENT of SARS-CoV-2 Without HOSPITALIZATION as a RISK FACTOR for ACUTE KIDNEY INJURY

Typeobservational_patient_registrySponsorUniversity of California, San FranciscoRan2021 to 2027Enrolled2,000ConditionsSARS-CoV Infection, Covid19, Corona Virus Infection, Acute Kidney InjuryArmsUrine Collection
3 · Its place in the literature

Who cites it

123 citing papers in PubMed, 1 synthesis or guideline pooled it, 201 citations in OpenAlex.

  1. Pooled it
  2. A pilot study to assess the circulating renin-angiotensin system in COVID-19 acute respiratory failure.American journal of physiology. Lung cellular and molecular physiology · 2021
    Trial
  3. Article
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  8. The relationship between estrogen and renin angiotensin system components in the context of hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Review
  9. Article
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  12. Article
  13. Review
  14. Article
  15. Altered kidney distribution and loss of ACE2 into the urine in acute kidney injury.American journal of physiology. Renal physiology · 2024
    Article
  16. Review
  17. Review
  18. Review
  19. Current drug discovery technologies · 2024
    Article
  20. Review

63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Peter SerfozoFrom the Division of Nephrology and Hypertension, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL (P.S., J.W., G.G., A.S., M.Y., P.L., J.J., D.B.).
Jan WysockiFrom the Division of Nephrology and Hypertension, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL (P.S., J.W., G.G., A.S., M.Y., P.L., J.J., D.B.).
Gvantca GuluaFrom the Division of Nephrology and Hypertension, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL (P.S., J.W., G.G., A.S., M.Y., P.L., J.J., D.B.).
Arndt SchulzeFrom the Division of Nephrology and Hypertension, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL (P.S., J.W., G.G., A.S., M.Y., P.L., J.J., D.B.).
Minghao YeFrom the Division of Nephrology and Hypertension, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL (P.S., J.W., G.G., A.S., M.Y., P.L., J.J., D.B.).
Pan LiuFrom the Division of Nephrology and Hypertension, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL (P.S., J.W., G.G., A.S., M.Y., P.L., J.J., D.B.).
Jing JinFrom the Division of Nephrology and Hypertension, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL (P.S., J.W., G.G., A.S., M.Y., P.L., J.J., D.B.).
Michael BaderCharité-Universitätsmedizin Berlin, Germany (P.S., G.G., A.S., M.B.).
Timo MyöhänenDivision of Pharmacology and Pharmacotherapy (T.M.), University of Helsinki, Finland.
J Arturo García-HorsmanRegenerative Pharmacology (J.A.G.-H.), University of Helsinki, Finland.
Daniel BatlleFrom the Division of Nephrology and Hypertension, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL (P.S., J.W., G.G., A.S., M.Y., P.L., J.J., D.B.).
Northwestern University · USUniversity of Helsinki · FICharité - Universitätsmedizin Berlin · DE

Funding

Strategies for ACE2 Amplification to Treat Diabetic Kidney DiseaseR01DK080089 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BATLLE, DANIEL · 2009 to 2012
$1.3M
Urinary Renin Angiotensin System in DiabetesR01DK104785 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BATLLE, DANIEL · 2015 to 2017
$939k
NIDDK NIH HHS R01 DK080089NIDDK NIH HHS R01 DK104785
6 · The paper itself

Abstract

The Ang II (Angiotensin II)-Angiotensin-(1-7) axis of the Renin Angiotensin System encompasses 3 enzymes that form Angiotensin-(1-7) [Ang-(1-7)] directly from Ang II: ACE2 (angiotensin-converting enzyme 2), PRCP (prolylcarboxypeptidase), and POP (prolyloligopeptidase). We investigated their relative contribution to Ang-(1-7) formation in vivo and also ex vivo in serum, lungs, and kidneys using models of genetic ablation coupled with pharmacological inhibitors. In wild-type (WT) mice, infusion of Ang II resulted in a rapid increase of plasma Ang-(1-7). In

Indexed as

Angiotensin-Converting Enzyme 2Angiotensin IAngiotensin IIAnimalsBlood PressureCarboxypeptidasesMaleMiceMice, KnockoutPeptide FragmentsPeptidyl-Dipeptidase AProlyl OligopeptidasesRenin-Angiotensin SystemSerine EndopeptidasesAce2 protein, mouseAngiotensin-Converting Enzyme 2Angiotensin Iangiotensin I (1-7)Angiotensin IICarboxypeptidaseslysosomal Pro-X carboxypeptidasePeptide FragmentsPeptidyl-Dipeptidase AProlyl OligopeptidasesSerine Endopeptidasesangiotensinshypertensionrenin-angiotensin system

Identifiers

PMID31786979
PMCPMC7286421
OpenAlexW2994488898

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.