Evidence map›Paper›PMID 31786976›Full record

ArticleHypertension (Dallas, Tex. : 1979)2020

Adenosine, Via A

Raghvendra K Dubey, Isabella Baruscotti, Ruth Stiller, Juergen Fingerle, Delbert G Gillespie, Zaichuan Mi, Brigitte Leeners, Bruno Imthurn, Marinella Rosselli, Edwin K Jackson

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Dipyridamole and vascular healing following stent implantation.Frontiers in cardiovascular medicine · 2023
    Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Raghvendra K DubeyFrom the Department of Obstetrics and Gynecology, Clinic for Reproductive Endocrinology, University Hospital Zurich (R.K.D., I.B., R.S., B.L., B.I., M.R.).
Isabella BaruscottiFrom the Department of Obstetrics and Gynecology, Clinic for Reproductive Endocrinology, University Hospital Zurich (R.K.D., I.B., R.S., B.L., B.I., M.R.).
Ruth StillerFrom the Department of Obstetrics and Gynecology, Clinic for Reproductive Endocrinology, University Hospital Zurich (R.K.D., I.B., R.S., B.L., B.I., M.R.).
Juergen FingerleNMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen, Reutlingen, Germany (J.F.).
Delbert G GillespieDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine (R.K.D., D.G.G., Z.M., E.K.J.).
Zaichuan MiDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine (R.K.D., D.G.G., Z.M., E.K.J.).
Brigitte LeenersFrom the Department of Obstetrics and Gynecology, Clinic for Reproductive Endocrinology, University Hospital Zurich (R.K.D., I.B., R.S., B.L., B.I., M.R.).
Bruno ImthurnFrom the Department of Obstetrics and Gynecology, Clinic for Reproductive Endocrinology, University Hospital Zurich (R.K.D., I.B., R.S., B.L., B.I., M.R.).
Marinella RosselliFrom the Department of Obstetrics and Gynecology, Clinic for Reproductive Endocrinology, University Hospital Zurich (R.K.D., I.B., R.S., B.L., B.I., M.R.).
Edwin K JacksonDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine (R.K.D., D.G.G., Z.M., E.K.J.).
University of Pittsburgh · USUniversity of Zurich · CH

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4M
Role of Renal Dipeptidyl Peptidase IVR01HL069846 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JACKSON, EDWIN KERRY · 2003 to 2020
$6.6M
The Guanosine-Adenosine MechanismR01HL109002 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JACKSON, EDWIN KERRY · 2012 to 2023
$5.1M
Adenosine in Renal Sympathetic NeurotransmissionR01DK091190 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JACKSON, EDWIN KERRY · 2011 to 2020
$3.4M
NHLBI NIH HHS R01 HL069846NHLBI NIH HHS R01 HL109002NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R01 DK091190
6 · The paper itself

Abstract

c-Kit+ progenitor smooth muscle cells (P-SMCs) can develop into SMCs that contribute to injury-induced neointimal thickening. Here, we investigated whether adenosine reduces P-SMC migration and proliferation and whether this contributes to adenosine's inhibitory actions on neointima formation. In human P-SMCs, 2-chloroadenosine (stable adenosine analogue) and BAY60-6583 (A

Indexed as

2-ChloroadenosineAdenineAdenosineAdenosine A2 Receptor AgonistsAminopyridinesCell MovementCell ProliferationCyclic AMPHumansMuscle, Smooth, VascularMyocytes, Smooth MusclePhenethylaminesPhosphorylationProto-Oncogene Proteins c-aktReceptor, Adenosine A2B2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine2-ChloroadenosineAdenineAdenosineAdenosine A2 Receptor AgonistsAminopyridinesBAY 60-6583Cyclic AMPPhenethylaminesProto-Oncogene Proteins c-aktReceptor, Adenosine A2Badenosineadult stem cellsneointimaphosphorylationvascular remodeling

Identifiers

PMID31786976
PMCPMC7009319
OpenAlexW2993560447

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.