Evidence map›Paper›PMID 31786960›Full record

ArticleThe Annals of otology, rhinology, and laryngology2020

Efficacy of Multi-Modal Migraine Prophylaxis Therapy on Hyperacusis Patients.

Mehdi Abouzari, Donald Tan, Brooke Sarna, Yaser Ghavami, Khodayar Goshtasbi, Erica M Parker, Harrison W Lin, Hamid R Djalilian

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Annals of otology, rhinology, and laryngology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Auditory pathways in migraine and vestibular migraine: New insights into sound sensitivity and spectral resolution dysfunction.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  3. Migraine Features in Patients With Sudden Sensorineural Hearing Loss.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. A proposed association between subjective nonpulsatile tinnitus and migraine.World journal of otorhinolaryngology - head and neck surgery · 2023
    Review
  10. Article
  11. [Hyperacusis: a mini review].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021
    Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Mehdi AbouzariDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, CA, USA.
Donald TanDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, CA, USA.
Brooke SarnaDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, CA, USA.
Yaser GhavamiDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, CA, USA.
Khodayar GoshtasbiDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, CA, USA.
Erica M ParkerDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, CA, USA.
Harrison W LinDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, CA, USA.
Hamid R DjalilianDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, CA, USA.
University of California, Irvine · US

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
NRSA Training CoreTL1TR001415 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAIOZZO, VINCENT JAMES, HEAD, ELIZABETH · 2015 to 2023
$4.2M
NCATS NIH HHS TL1 TR001415NCATS NIH HHS UL1 TR001414
6 · The paper itself

Abstract

objectivesTo evaluate the efficacy of a multi-modal migraine prophylaxis therapy for patients with hyperacusis.

methodsIn a prospective cohort, patients with hyperacusis were treated with a multi-modal step-wise migraine prophylactic regimen (nortriptyline, verapamil, topiramate, or a combination thereof) as well as lifestyle and dietary modifications. Pre- and post-treatment average loudness discomfort level (LDL), hyperacusis discomfort level measured by a visual analogue scale (VAS), and scores on the modified Khalfa questionnaire for severity of hyperacusis were compared.

resultsTwenty-two of the 25 patients (88%) reported subjective resolution of their symptoms following treatment. Post-treatment audiograms showed significant improvement in average LDL from 81.3 ± 3.2 dB to 86.4 ± 2.6 dB (

conclusionsThe majority of patients with hyperacusis demonstrated symptomatic improvement from migraine prophylaxis therapy, as indicated by self-reported and audiometric measures. Our findings indicate that, for some patients, hyperacusis may share a pathophysiologic basis with migraine disorder and may be successfully managed with multimodal migraine prophylaxis therapy.

Indexed as

Quality of LifeAdrenergic Uptake InhibitorsAdultAgedAnticonvulsantsDrug Therapy, CombinationFemaleFollow-Up StudiesHearingHearing TestsHumansHyperacusisMaleMiddle AgedMigraine DisordersNortriptylineAdrenergic Uptake InhibitorsAnticonvulsantsNortriptylineTopiramateVasodilator AgentsVerapamilhyperacusismigrainemigraine treatmentmodified Khalfa questionnairequality of life

Identifiers

PMID31786960
PMCPMC8040770
OpenAlexW2993518606

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.