Evidence map›Paper›PMID 31786828›Full record

ArticleMolecular nutrition & food research2020

Red Raspberry Polyphenols Attenuate High-Fat Diet-Driven Activation of NLRP3 Inflammasome and its Paracrine Suppression of Adipogenesis via Histone Modifications.

Rong Fan, Mikyoung You, Ashley M Toney, Judy Kim, David Giraud, Yibo Xian, Feng Ye, Liwei Gu, Amanda E Ramer-Tait, Soonkyu Chung

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular nutrition & food research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Rong FanDepartment of Nutrition and Health Sciences, University of Nebraska, Lincoln, NE, 68583, USA.
Mikyoung YouDepartment of Nutrition and Health Sciences, University of Nebraska, Lincoln, NE, 68583, USA.
Ashley M ToneyDepartment of Nutrition and Health Sciences, University of Nebraska, Lincoln, NE, 68583, USA.
Judy KimDepartment of Nutrition and Health Sciences, University of Nebraska, Lincoln, NE, 68583, USA.
David GiraudDepartment of Nutrition and Health Sciences, University of Nebraska, Lincoln, NE, 68583, USA.
Yibo XianDepartment of Food Science and Technology, University of Nebraska, Lincoln, NE, 68583, USA.
Feng YeFood Science and Human Nutrition Department, University of Florida, Gainesville, FL, 32611, USA.
Liwei GuFood Science and Human Nutrition Department, University of Florida, Gainesville, FL, 32611, USA.
Amanda E Ramer-TaitDepartment of Food Science and Technology, University of Nebraska, Lincoln, NE, 68583, USA.
Soonkyu ChungDepartment of Nutrition and Health Sciences, University of Nebraska, Lincoln, NE, 68583, USA.ORCID 0000-0001-6279-7017
University of Nebraska–Lincoln · USUniversity of Florida · US

Funding

The role of stress in the fetal origin of obesity and metabolic dysfunctionP20GM104320 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI ZEMPLENI, JANOS · 2014 to 2024
$24.9M
Epigenetic Regulation of fetal BAT Development via Maternal N-3 PUFA intakeR21HD094273 · NICHD · UNIVERSITY OF NEBRASKA LINCOLN · PI CHUNG, SOONKYU · 2019 to 2020
$416k
NICHD NIH HHS R21 HD094273NIGMS NIH HHS P20 GM104320
6 · The paper itself

Abstract

scopeThe authors aim to investigate the mechanisms by which red raspberry (RR) polyphenolic fractions regulate obesity and inflammation with an emphasis on the crosstalk between adipose tissue macrophages (ATM) and adipocyte progenitors. METHODS AND

resultsC57BL/6 male mice are fed either a high-fat (HF) diet or an HF diet supplemented with a RR polyphenolic fraction from whole fruit, pulp, or seed. Supplementation with pulp significantly increases energy expenditure and reduces HF-diet-induced obesity and insulin resistance. The pulp, and to a lesser extent, whole polyphenols, decreases the recruitment of ATM, activation of the nod-like receptor protein 3 (NLRP3) inflammasome, and adipocyte hypertrophy, which is associated with epigenetic modulation of adipogenesis (e.g., H3K27Ac, H3K9Ac). Results from an IL-1β reporter assay in J774 macrophages recapitulate the inhibitory role of RR polyphenols on NLRP3 inflammasome activation. Using conditioned media from macrophages, it is demonstrated that RR polyphenols reverse the IL-1β-mediated epigenetic suppression of H3K27Ac in adipocyte progenitor cells.

conclusionsRR polyphenols from pulp and whole fruit serve as an inhibitor for NLRP3 inflammasome activation and an epigenetic modifier to regulate adipogenesis, which confers resistance against diet-induced obesity and metabolic dysfunction.

Indexed as

AdipocytesAdipogenesisAnimalsDiet, High-FatHistonesInflammasomesInsulin ResistanceMacrophagesMaleMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinObesityPanniculitisPolyphenolsProtein Processing, Post-TranslationalRubusHistonesInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mousePolyphenolsadipogenesishistone modificationnod-like receptor protein 3 inflammasomepolyphenolsred raspberry

Identifiers

PMID31786828
PMCPMC9045478
OpenAlexW2990137076

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.