Evidence map›Paper›PMID 31786770›Full record

ArticleJournal of youth and adolescence2020

Time-varying Effects of GABRG1 and Maladaptive Peer Behavior on Externalizing Behavior from Childhood to Adulthood: Testing Gene × Environment × Development Effects.

Elisa M Trucco, Songshan Yang, James J Yang, Robert A Zucker, Runze Li, Anne Buu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of youth and adolescence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Elisa M TruccoPsychology Department and the Center for Children and Families, Florida International University, Miami, FL, USA. etrucco@fiu.edu.ORCID http://orcid.org/0000-0002-9922-8608
Songshan YangPennsylvania State University, University Park, PA, USA.
James J YangDepartment of Biostatistics and Data Science, University of Texas Health Scince Center, Houston, TX, USA.
Robert A ZuckerPsychiatry Department, University of Michigan, Ann Arbor, MI, USA.
Runze LiPennsylvania State University, University Park, PA, USA.
Anne BuuDepartment of Health Promotion and Behavioral Sciences, University of Texas Health Science Center, Houston, TX, USA.
Pennsylvania State University · USThe University of Texas Health Science Center at Houston · USFlorida Department of Children and Families · USUniversity of Michigan · US

Funding

The FIU Research Center in a Minority Institution (FIU-RCMI)U54MD012393 · NIMHD · FLORIDA INTERNATIONAL UNIVERSITY · PI ERIC F WAGNER · 2017 to 2026
$32.1M
Southeast Asia Malaria Research CenterU19AI089672 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI CUI, LIWANG · 2010 to 2023
$28.9M
Pilot, Mentoring, and Professional Development CoreP50DA039838 · NIDA · PENNSYLVANIA STATE UNIVERSITY, THE · PI BRAY, BETHANY C. · 2015 to 2019
$13.9M
Family Study of Risk for Alcoholism Over the Life CourseR37AA007065 · NIAAA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZUCKER, ROBERT ALPERT · 2003 to 2012
$10.6M
RISK AND COPING IN CHILDREN OF ALCOHOLICSR01AA007065 · NIAAA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HEITZEG, MARY M · 1987 to 2017
$6.1M
Measurement and Methodology for Daily Patterns of Drug Use and Related BehaviorsR01DA035183 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BUU, YUH-PEY ANNE, CUNNINGHAM, REBECCA M. · 2013 to 2017
$2.6M
Developing Methodology to examine causal mediation of Time-Varying Effects in Smoking Cessation TreatmentsR01CA229542 · NCI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI COFFMAN, DONNA LYNN · 2018 to 2021
$1.3M
Penn State Biomedical Big Data to Knowledge (B2D2K) Training ProgramT32LM012415 · NLM · PENNSYLVANIA STATE UNIVERSITY, THE · PI BROACH, JAMES R., HONAVAR, VASANT G. · 2016 to 2020
$1.2M
Environment, Genes, and Temperament on the Development of Alcohol Use DisorderK08AA023290 · NIAAA · FLORIDA INTERNATIONAL UNIVERSITY · PI TRUCCO, ELISA MARIA · 2015 to 2019
$818k
National Science Foundation DMS1512422NCI NIH HHS R01 CA229542NIAAA NIH HHS K08 AA023290NIAAA NIH HHS R01 AA007065NIAAA NIH HHS R37 AA007065NIAID NIH HHS U19 AI089672NIDA NIH HHS P50 DA039838NIDA NIH HHS R01 DA035183NIMHD NIH HHS U54 MD012393NLM NIH HHS T32 LM012415
6 · The paper itself

Abstract

Engagement in externalizing behavior is problematic. Deviant peer affiliation increases risk for externalizing behavior. Yet, peer effects vary across individuals and may differ across genes. This study determines gene × environment × development interactions as they apply to externalizing behavior from childhood to adulthood. A sample (n = 687; 68% male, 90% White) of youth from the Michigan Longitudinal Study was assessed from ages 10 to 25. Interactions between γ-amino butyric acid type A receptor γ1 subunit (GABRG1; rs7683876, rs13120165) and maladaptive peer behavior on externalizing behavior were examined using time-varying effect modeling. The findings indicate a sequential risk gradient in the influence of maladaptive peer behavior on externalizing behavior depending on the number of G alleles during childhood through adulthood. Individuals with the GG genotype are most vulnerable to maladaptive peer influences, which results in greater externalizing behavior during late childhood through early adulthood.

Indexed as

Adolescent BehaviorGenetic Predisposition to DiseaseGenotypeReceptors, GABA-AAdolescentAdultAllelesChildFemaleHumansInternal-External ControlLongitudinal StudiesMaleMichiganPeer GroupYoung AdultGABRG1 protein, humanReceptors, GABA-AExternalizing behaviorGABRG1GenesPeersTVEM

Identifiers

PMID31786770
PMCPMC7260088
OpenAlexW2990074326

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.