ArticleGeroScience2020
Ellagic acid prolongs the lifespan of Drosophila melanogaster.
Article in GeroScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed, 35 citations in OpenAlex.
- Ellagic acid counteracts mercury chloride-induced oxidative stress and thiol oxidation in Drosophila melanogaster.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- Chlorophyll Supplementation Delays Aging inNutrients · 2026Article
- Reserpine prolongs lifespan but compromises locomotion and heat-stress resilience in Drosophila melanogaster.npj aging · 2026Article
- Microbiota-derived indole acetic acid extends lifespan through the AhR-Sirt2 pathway inmSystems · 2025Article
- A Natural Autophagy Activator Castanea crenata Flower Alleviates Skeletal Muscle Ageing.Journal of cachexia, sarcopenia and muscle · 2025Article
- Evaluation of the antioxidant and longevity-promoting effects of white tea extract inFrontiers in nutrition · 2025Article
- Investigating the neuroprotective effects of strawberry extract against diesel soot-induced motor dysfunction in Drosophila: an in-vivo and in-silico study.In silico pharmacology · 2025Article
- Review
- Cut homeodomain transcription factor is a novel regulator of growth and morphogenesis of cortex glia niche around neural cells.Genetics · 2024Article
- Comparison of toxic effects of 5 macrofungi against Drosophila melanogaster.Journal of insect science (Online) · 2023Article
- Review
- Insect Models in Nutrition Research.Biomolecules · 2022Review
- Evaluation of ellagic acid and gallic acid as efflux pump inhibitors in strains of Staphylococcus aureus.Biology open · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wild-type Canton-S flies of Drosophila melanogaster were treated with ellagic acid at 100 μM and 200 μM concentrations. Longevity assay showed male flies fed with 200 μM ellagic acid displayed longer mean lifespan and maximum lifespan than control flies. Female flies fed with 200 μM ellagic acid laid less number of eggs than control. The eclosion time was less in female flies fed with 200 μM ellagic acid. Ellagic acid fed female flies performed better than male flies and control flies for heat shock tolerance and starvation stress. Male flies treated with 100 μM ellagic acid recovered faster from cold shock compared with control flies. Male and female flies treated with ellagic acid displayed increased survival following exposure to 5% hydrogen peroxide. Gene expression studies displayed upregulated expressions of CAT, dFOXO, ATG1, and SOD2 in ellagic acid-treated male flies, and upregulated expressions of dFOXO, CAT, and SOD2 in ellagic acid-treated female flies. Results from these studies show the pro-longevity effect of ellagic acid on Drosophila melanogaster.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.