Evidence map›Paper›PMID 31786728›Full record

ArticleMetabolic brain disease2020

Ischemia-related changes of fat-mass and obesity-associated protein expression in the gerbil hippocampus.

Woosuk Kim, Min Soo Kang, Tae Hyeong Kim, Dae Young Yoo, Joon Ha Park, Hyo Young Jung, Moo-Ho Won, Jung Hoon Choi, In Koo Hwang

Abstract read
PubMed Publisher
In one paragraph

Article in Metabolic brain disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. mFrontiers in neurology · 2022
    Review
  4. Epitranscriptomic regulation by mJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Woosuk KimDepartment of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science, 85-508 Seoul National University, 1 Gwanak-ro, Seoul, 08826, South Korea.
Min Soo KangDepartment of Anatomy, College of Veterinary Medicine and Institute of Veterinary Science, 411-105 Kangwon National University, 1 Kangwondaehak-gil, Chuncheon, 24341, South Korea.
Tae Hyeong KimDepartment of Anatomy, College of Veterinary Medicine and Institute of Veterinary Science, 411-105 Kangwon National University, 1 Kangwondaehak-gil, Chuncheon, 24341, South Korea.
Dae Young YooDepartment of Anatomy, College of Medicine, Soonchunhyang University, Cheonan, 31151, South Korea.
Joon Ha ParkDepartment of Anatomy, College of Korean Medicine,, Dongguk University, Gyeongju, 38066, Republic of Korea.
Hyo Young JungDepartment of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science, 85-508 Seoul National University, 1 Gwanak-ro, Seoul, 08826, South Korea.
Moo-Ho WonDepartment of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, 24341, South Korea.
Jung Hoon ChoiDepartment of Anatomy, College of Veterinary Medicine and Institute of Veterinary Science, 411-105 Kangwon National University, 1 Kangwondaehak-gil, Chuncheon, 24341, South Korea. jhchoi@kangwon.ac.kr.
In Koo HwangDepartment of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science, 85-508 Seoul National University, 1 Gwanak-ro, Seoul, 08826, South Korea. vetmed2@snu.ac.kr.ORCID http://orcid.org/0000-0002-0533-4638
Kangwon National University · KRSeoul National University · KRDongguk University · KRSoonchunhyang University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fat-mass and obesity-associated protein (Fto) plays important roles in energy metabolism. It also acts as a demethylase and is most abundantly found in the brain. In the present study, we examined the spatial and temporal changes of Fto immunoreactivity after five minutes of transient forebrain ischemia in the hippocampus. In the control group, Fto immunoreactivity was mainly observed in the nucleus of pyramidal cells in the CA1 and CA3 regions as well as the polymorphic layer, granule cell layer, and subgranular zone of the dentate gyrus. Fto immunoreactivity was transiently, but not significantly, increased in the hippocampal CA3 region and the dentate gyrus two days after ischemia compared to mice without ischemia in the sham-operated group. Four days after ischemia, low Fto immunoreactivity was observed in the stratum pyramidale of the CA1 region because of neuronal death, but Fto immunoreactive cells were abundantly detected in the stratum pyramidale of the CA3 region, which is relatively resistant to ischemic damage. Thereafter, Fto immunoreactivity progressively decreased in the hippocampal CA1 and CA3 regions and the dentate gyrus until ten days after ischemia. At this time-point, Fto immunoreactivity was significantly lower in the hippocampal CA1 and CA3 regions and the dentate gyrus compared to that in the sham-operated group. The reduction of Fto immunoreactive structures in the hippocampus may be associated with impairments in Fto-related hippocampal function.

Indexed as

Alpha-Ketoglutarate-Dependent Dioxygenase FTOAnimalsBrain IschemiaGene ExpressionGerbillinaeHippocampusMaleAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, mouseFtoGerbilHippocampusTransient forebrain ischemia

Identifiers

PMID31786728
OpenAlexW2992729046

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.