ArticleMetabolic brain disease2020
Shuangxia decoction alleviates p-chlorophenylalanine induced insomnia through the modification of serotonergic and immune system.
Article in Metabolic brain disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
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13 citing papers in PubMed, 42 citations in OpenAlex.
- [Correlations of calmodulin and neurotransmitters with polysomnographic parameters in patients with chronic insomnia disorder].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
- Multi-target regulatory mechanisms and clinical assessment of natural products for insomnia: a review.Frontiers in pharmacology · 2026Review
- Senegenin regulates the mechanism of insomnia through the Keap1/Nrf2/PINK1/Parkin pathway mediated by GAD67.Journal of sleep research · 2025Article
- Abdominal massage modulates gut microbiota and brain-gut peptides in insomnia model rats.Frontiers in microbiology · 2025Article
- Research progress on the effect of medicine and food homology resources for sleep improvement.Heliyon · 2024Review
- The effect of modified Qiyuan paste on mice with low immunity and sleep deprivation by regulating GABA nerve and immune system.Chinese medicine · 2024Article
- Study on the Mechanism of Jiaotai Pill Intervention on Insomnia Animal Model Based on Gut Microbiome and Metabolomics.Evidence-based complementary and alternative medicine : eCAM · 2023Article
- PtNPs/Short MWCNT-PEDOT: PSS-Modified Microelectrode Array to Detect Neuronal Firing Patterns in the Dorsal Raphe Nucleus and Hippocampus of Insomnia Rats.Micromachines · 2022Article
- Neuroprotective effect of Ziziphi Spinosae Semen on rats with p-chlorophenylalanine-induced insomniaFrontiers in pharmacology · 2022Article
- Loganin ameliorates depression-like behaviors of mice via modulation of serotoninergic system.Psychopharmacology · 2021Article
- Nyctinastic herbs decoction improves para-chlorophenylalanine-induced insomnia by regulating the expression level of neurotransmitters.Annals of translational medicine · 2021Article
- Schisandrin B exerts hypnotic effects in PCPA-treated rats by increasing hypothalamic 5-HT and γ-aminobutyric acid levels.Experimental and therapeutic medicine · 2020Article
- Uncovering the pharmacological mechanism of the effects of the Banxia-Xiakucao Chinese Herb Pair on sleep disorder by a systems pharmacology approach.Scientific reports · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As a Traditional Chinese Medicine (TCM), Shuangxia Decoction (SXD) has been used to treat insomnia in oriental countries for more than thousands of years and it presents remarkable clinical effects. However, its active pharmacological fraction and the mechanism of sedative-hypnotic effects have not been explored. In this paper, we investigated active pharmacological fraction and revealed the detailed mechanisms underlying the sedative-hypnotic effects of SXD. It showed that SXD water extract compared to ethanol extract possessed better sedative effects on locomotion activity in normal mice and increased sleep duration in subhypnotic dose of sodium pentobarbital-treated mice. SXD alleviated p-chlorophenylalanine (PCPA) -induced insomnia by increasing the content of 5-HT in cortex [F (4, 55) = 12.67], decreasing the content of dopamine (DA) and norepinephrine (NE). Furthermore, SXD enhanced the expression of 5-HT
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