Evidence map›Paper›PMID 31786682›Full record

ArticleSurgery today2020

An increase in the peripheral lymphocyte-to-monocyte ratio after primary site resection is associated with a prolonged survival in unresectable colorectal carcinoma.

Nobuki Ichikawa, Shigenori Homma, Tadashi Yoshida, Tomoko Mitsuhashi, Hiroaki Iijima, Kazuhiro Ogasawara, Keizo Kazui, You Kamiizumi, Futoshi Kawamata, Akinobu Taketomi

Abstract read
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Article in Surgery today, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nobuki IchikawaDepartment of Gastroenterological Surgery I, Graduate School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, 060-8638, Japan.ORCID http://orcid.org/0000-0002-8934-9684
Shigenori HommaDepartment of Gastroenterological Surgery I, Graduate School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, 060-8638, Japan. homma.s@nifty.com.
Tadashi YoshidaDepartment of Gastroenterological Surgery I, Graduate School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, 060-8638, Japan.
Tomoko MitsuhashiDepartment of Surgical Pathology, Hokkaido University Hospital, N-14, W-5, Kita-ku, Sapporo, 060-8638, Japan.
Hiroaki IijimaClinical Research and Medical Innovation Center, Hokkaido University Hospital, N-14, W-5, Kita-ku, Sapporo, 060-8638, Japan.
Kazuhiro OgasawaraDepartment of Surgery, Kushiro Rosai Hospital, Japan Labour Health and Welfare Organization, 13-23 Nakazono-cho, Kushiro, Hokkaido, 085-8533, Japan.
Keizo KazuiDepartment of Surgery, Hokkaido Hospital, Japan Community Healthcare Organization, Nakanoshima 1-8-3-18, Toyohira-ku, Sapporo, 062-8618, Japan.
You KamiizumiDepartment of Surgery, Iwamizawa Municipal Hospital, West 7-2, 9 jou, Iwamizawa, 068-8555, Japan.
Futoshi KawamataDepartment of Gastroenterological Surgery I, Graduate School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, 060-8638, Japan.
Akinobu TaketomiDepartment of Gastroenterological Surgery I, Graduate School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, 060-8638, Japan.

Funding

Grant-in-Aid for Young Scientists, Japan society for the Promotion of Science grant numbers 18K16294
6 · The paper itself

Abstract

purposeThe prognostic benefits of primary tumor resection in patients with unresectable distant metastatic colorectal cancer remain unclear. A high pre-treatment lymphocyte-to-monocyte ratio (LMR) was previously shown to be associated with a better prognosis. We assessed whether or not primary tumor resection was associated with an improved survival if the peripheral lymphocyte-to-monocyte ratio increased after primary site resection.

methodsThe survival in 64 and 59 patients with and without primary tumor resection, respectively, was retrospectively compared. After resection, the survival in 39 patients with a postoperatively increased LMR (LMR-increase) and 25 patients with a decreased LMR (LMR-decrease) was compared.

resultsPrimary tumor resection prolonged the median survival more frequently in cases of non-differentiated adenocarcinoma, obstructive symptoms, high serum albumin levels, and no lymph-node metastasis than in others. Cox regression showed that the potential independent prognostic variable was non-resection of the primary lesion. After resection, the median survival in the LMR-increase vs. LMR-decrease groups was significantly different (27.3 vs. 20.8 months). There were no marked differences in patient background characteristics between the groups, except for in the number of pre-operative peripheral blood lymphocytes. The resected specimens showed significantly lower CD8

conclusionsPrimary tumor resection in patients with unresectable metastatic colorectal cancer may be associated with an improved survival, especially when the LMR is increased after primary tumor resection.

Indexed as

Leukocyte CountAgedColorectal NeoplasmsFemaleHumansLymphocytesMaleMiddle AgedMonocytesColorectal cancerExcisionLymphocyte/monocyte ratioMetastaticPrimary site tumor

Identifiers

PMID31786682

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.