Evidence map›Paper›PMID 31786652›Full record

ArticleInternational journal of colorectal disease2020

Pre-treatment ADC image-based random forest classifier for identifying resistant rectal adenocarcinoma to neoadjuvant chemoradiotherapy.

Chun Yang, Ze-Kun Jiang, Li-Heng Liu, Meng-Su Zeng

Abstract read
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In one paragraph

Article in International journal of colorectal disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  4. The Role of Radiomics in Rectal Cancer.Journal of gastrointestinal cancer · 2023
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  12. Research progress of omics technology in the field of tumor resistance: From singleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chun YangDepartment of Radiology, Zhongshan Hospital, Fudan University, No. 180, Fenglin Road, Shanghai, 200032, China.
Ze-Kun JiangShandong Key Laboratory of Medical Physics and Image Processing Technology, School of Physics and Electronics, Shandong Normal University, Jinan, Shandong, China.
Li-Heng LiuDepartment of Radiology, Zhongshan Hospital, Fudan University, No. 180, Fenglin Road, Shanghai, 200032, China. llh9821@163.com.ORCID http://orcid.org/0000-0002-3666-279X
Meng-Su ZengDepartment of Radiology, Zhongshan Hospital, Fudan University, No. 180, Fenglin Road, Shanghai, 200032, China.

Funding

National Natural Science Foundation of China NO. 81701656
6 · The paper itself

Abstract

objectiveTo develop a predicting model for tumor resistance to neoadjuvant chemoradiotherapy (NCRT) in locally advanced rectal cancer (LARC) by using pre-treatment apparent diffusion coefficient (ADC) image-derived radiomics features.

methodA total of 89 patients with LARC were randomly assigned into training (N = 66) and testing cohorts (N = 23) at the ratio of 3:1. Radiomics features were derived from manually determined tumor region of pre-treatment ADC images. Random forest algorithm was used to determine the most relevant features and then to construct a predicting model for identifying resistant tumor. Stability and diagnostic performance of the random forest model was evaluated with the testing cohort.

resultsThe top 10 most relevant features (entropy

conclusionThe random forest classifier based on radiomics features derived from pre-treatment ADC images have the potential to predict tumor resistance to NCRT in patients with LARC, and the use of predicting model may facilitate individualized management of rectal cancer.

Indexed as

AlgorithmsChemoradiotherapyDiffusion Magnetic Resonance ImagingDrug Resistance, NeoplasmNeoadjuvant TherapyAdenocarcinomaAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedObserver VariationRectal NeoplasmsReproducibility of ResultsDiffusion-weighted MRIDrug resistanceMachine learningNeoadjuvant therapyNeoplasmRectal cancer

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.