ArticleAcademic radiology2020
Generalized Linear Binning to Compare Hyperpolarized
Article in Academic radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Adapted Linear Binning Method to Assess Pulmonary Ventilation and Perfusion in Children Using Lung Matrix Pencil Decomposition (MP)-MRI.Magnetic resonance in medicine · 2026Article
- Comparison of Single-Breath and Multi-Breath Xe-MRI in the Longitudinal Assessment of Treatment in Children With Cystic Fibrosis.Journal of magnetic resonance imaging : JMRI · 2026Article
- Comparing Mean-anchored Generalized Linear Binning with Established Methods to Quantify Xenon-129 Ventilation Defect Percentage.Academic radiology · 2026Article
- Xenon-129 magnetic resonance imaging detects ongoing ventilation improvements in people with cystic fibrosis receiving highly effective modulator therapy.Annals of the American Thoracic Society · 2026Article
- Optimizing Xenon 129 Ventilation MRI in Cystic Fibrosis with Spiral Imaging and Flip-Angle Correction.Radiology. Cardiothoracic imaging · 2025Article
- Establishing standardized healthy reference distributions and values for multisiteMagnetic resonance in medicine · 2025Article
- Article
- Quantifying abnormal alveolar microstructure in cystic fibrosis lung disease via hyperpolarizedJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2024Article
- Childhood to adulthood: Accounting for age dependence in healthy-reference distributions inMagnetic resonance in medicine · 2023Article
- Bias field correction in hyperpolarizedMagnetic resonance in medicine · 2022Article
- A dual center and dual vendor comparison study of automated perfusion-weighted phase-resolved functional lung magnetic resonance imaging with dynamic contrast-enhanced magnetic resonance imaging in patients with cystic fibrosis.Pulmonary circulation · 2022Article
- Regional Gas Exchange Measured byJournal of magnetic resonance imaging : JMRI · 2021Article
- Using hyperpolarizedJournal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- In vivo methods and applications of xenon-129 magnetic resonance.Progress in nuclear magnetic resonance spectroscopy · 2021Review
- QuantitativeScientific reports · 2020Article
- HyperpolarizedRespiratory medicineArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
rationaleHyperpolarized
methodsThis study included 36 patients who had undergone both multislice GRE ventilation and 3D radial gas exchange imaging. Images were then quantified by linear binning to classify voxels into one of four clusters: ventilation defect percentage (VDP), Low-, Medium- or High-ventilation percentage (LVP, MVP, HVP). For 3D radial images, linear binning thresholds were generalized using a Box-Cox rescaled reference histogram. We compared the cluster populations from the two ventilation acquisitions both numerically and spatially.
resultsInteracquisition Bland-Altman limits of agreement for the clusters between 3D radial vs GRE were (-7% to 5%) for VDP, (-10% to 14%) for LVP, and (-8% to 8%) for HVP. While binning maps were qualitatively similar between acquisitions, their spatial overlap was modest for VDP (Dice = 0.5 ± 0.2), and relatively poor for LVP (0.3 ± 0.1) and HVP (0.2 ± 0.1).
conclusionBoth acquisitions yield reasonably concordant VDP and qualitatively similar maps. However, poor regional agreement (Dice) suggests that the two acquisitions cannot yet be used interchangeably. However, further improvements in 3D radial resolution and reconciliation of bias field correction may well obviate the need for a dedicated ventilation scan in many cases.
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