ArticleCurrent biology : CB2019
Activation of Kappa Opioid Receptor Regulates the Hypothermic Response to Calorie Restriction and Limits Body Weight Loss.
Open access · greenAbstract read
In one paragraph
Article in Current biology : CB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- A Preoptic Neuronal Population Regulates Energy Expenditure and Balance.bioRxiv : the preprint server for biology · 2026Article
- Preoptic activation induces a torpor-like hypothermic and hypometabolic state that is cerebroprotective.bioRxiv : the preprint server for biology · 2025Article
- ParabrachialiScience · 2025Article
- Potential downsides of calorie restriction.Nature reviews. Endocrinology · 2025Review
- Neural circuits of long-term thermoregulatory adaptations to cold temperatures and metabolic demands.Nature reviews. Neuroscience · 2024Review
- Sex-specific negative affect-like behaviour and parabrachial nucleus activation induced by BNST stimulation in adult mice with adolescent alcohol history.Addiction biology · 2024Article
- Kappa opioid receptor activation increases thermogenic energy expenditure which drives increased feeding.iScience · 2023Article
- Peptidomic Analysis Reveals Seasonal Neuropeptide and Peptide Hormone Changes in the Hypothalamus and Pituitary of a Hibernating Mammal.ACS chemical neuroscience · 2023Article
- High Fat Diet Suppresses Energy Expenditure Via Neurons in the Brainstem.Neuroscience · 2023Article
- Interactions between central nervous system and peripheral metabolic organs.Science China. Life sciences · 2022Review
- Sex specific effects of buprenorphine on behavior, astrocytic opioid receptor expression and neuroinflammation after pediatric traumatic brain injury in mice.Brain, behavior, & immunity - health · 2022Article
- Neurons in the Dorsomedial Hypothalamus Promote, Prolong, and Deepen Torpor in the Mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Kappa-Opioid Receptor Blockade Ameliorates Obesity Caused by Estrogen Withdrawal via Promotion of Energy Expenditure through mTOR Pathway.International journal of molecular sciences · 2022Article
- A hypothalamomedullary network for physiological responses to environmental stresses.Nature reviews. Neuroscience · 2022Review
- Regulation of body weight and food intake by AGRP neurons during opioid dependence and abstinence in mice.Frontiers in neural circuits · 2022Article
- Article
- κ-Opioid Signaling in the Lateral Hypothalamic Area Modulates Nicotine-Induced Negative Energy Balance.International journal of molecular sciences · 2021Article
- Extended amygdala-parabrachial circuits alter threat assessment and regulate feeding.Science advances · 2021Article
- The kappa opioid receptor antagonist aticaprant reverses behavioral effects from unpredictable chronic mild stress in male mice.Psychopharmacology · 2020Article
- Metabolic adaptation to calorie restriction.Science signaling · 2020Article
Corrections and comments
- Commented on by
Authors and funding
13 authors at 2 institutions in 3 countries.
Rigo Cintron-ColonDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Christopher W JohnsonGraduate Program in Neuroscience, University of Washington, Seattle, WA 98195, USA.
J Rafael Montenegro-BurkeScripps Center for Metabolomics, The Scripps Research Institute, La Jolla, CA 92037, USA.
Carlos GuijasScripps Center for Metabolomics, The Scripps Research Institute, La Jolla, CA 92037, USA.
Lila FaulhaberDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Manuel Sanchez-AlavezDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA; Facultad de Medicina y Psicología, Universidad Autónoma de Baja California, Tijuana 22390, México.
Carlos A AguirreDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Kokila ShankarDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Mona SinghDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Andrea GalmozziDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Gary SiuzdakScripps Center for Metabolomics, The Scripps Research Institute, La Jolla, CA 92037, USA; Departments of Chemistry and Molecular Medicine, and Center for Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Enrique SaezDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Bruno ContiDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Biochemistry and Biophysics, Stockholm University, S-106 91 Stockholm, Sweden. Electronic address: bconti@scripps.edu.
Scripps Research Institute · USUniversity of Washington · US
Funding
Therapeutics Core (Page 286)P30MH062261 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BUCH, SHILPA J., FOX, HOWARD S · 2000 to 2021
$37.7MChemoproteomic Identification and Therapeutic Validation of Proteins of Metabolic SignificanceRC2DK114785 · NIDDK · SCRIPPS RESEARCH INSTITUTE, THE · PI CRAVATT, BENJAMIN F, SAEZ, ENRIQUE · 2017 to 2021
$8.2MProteomic Strategies for AIDS and Drug Abuse - HIV and METH CNS SynergyP01DA026146 · NIDA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI CIBOROWSKI, PAWEL S · 2008 to 2010
$2.9MMechanisms of Temperature RegulationR01GM113894 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI CONTI, BRUNO · 2016 to 2019
$1.6MXCMS Metabolomic Data TechnologyR01GM114368 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI SIUZDAK, GARY E · 2015 to 2018
$1.5MNIDA NIH HHS P01 DA026146NIDDK NIH HHS RC2 DK114785NIGMS NIH HHS R01 GM113894NIGMS NIH HHS R01 GM114368NIMH NIH HHS P30 MH062261
Abstract
Mammals maintain a nearly constant core body temperature (T
Indexed as
Analgesics, OpioidAnimalsBody Temperature RegulationBody WeightBrainCaloric RestrictionEnergy IntakeEnergy MetabolismFemaleHypothalamusMaleMiceMice, Inbred C57BLNeuronsReceptors, Opioid, kappaReceptors, Opioid, muAnalgesics, OpioidReceptors, Opioid, kappaReceptors, Opioid, mubody temperaturebody weightcalorie restrictiondietingdynorphinenergy expenditureenergy homeostasishypothermiakappa opioid receptor
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.