SynthesisNutrition journal2019
Association between micronutrient deficiency and acute respiratory infections in healthy adults: a systematic review of observational studies.
Synthesis in Nutrition journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Vitamin D supplementation for prevention of acute respiratory infections in older adults: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Micronutrients Deficiency, Supplementation and Novel Coronavirus Infections-A Systematic Review and Meta-Analysis.Nutrients · 2021Pooled it
- Zinc Supplementation Reduces Common Cold Duration among Healthy Adults: A Systematic Review of Randomized Controlled Trials with Micronutrients Supplementation.The American journal of tropical medicine and hygiene · 2020Pooled it
- Vitamin D and Lung Outcomes in Elderly COVID-19 Patients.Nutrients · 2021Trial
- Trial
- Assessment of serum vitamin D levels in children aged 0-17 years old in a Chinese population: a comprehensive study.Scientific reports · 2024Article
- Review
- Bee Pollen as Functional Food: Insights into Its Composition and Therapeutic Properties.Antioxidants (Basel, Switzerland) · 2023Review
- Knowledge and behaviors of using vitamin D to boost immunity against COVID-19 pandemic: A cross-sectional study in Saudi Arabia.Medicine · 2022Article
- Clinical nutrition approach in medical management of COVID-19 hospitalized patients: A narrative review.Nutrition and health · 2022Review
- The association between vitamin D status and COVID-19 in England: A cohort study using UK Biobank.PloS one · 2022Article
- Major dietary patterns in relation to disease severity, symptoms, and inflammatory markers in patients recovered from COVID-19.Frontiers in nutrition · 2022Article
- Status and influential factors of vitamin D among children aged 0 to 6 years in a Chinese population.BMC public health · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute respiratory infections (ARI), including the common cold causes significant morbidity and economical losses globally. Micronutrient deficiency may increase ARI incidence risk and its associated duration and severity among healthy adults, but evidence are inconclusive. This study aims to systematically review all observations on the association between single micronutrient deficiency and ARI incidence, duration and severity in healthy adults.
methodsSystematic literature searches were conducted in PubMed, Cochrane Library, Embase and Scopus databases. Eligible studies were assessed for the reporting and methodological quality. Adjusted summary statistics with their relevant 95% confidence intervals or interquartile ranges were extracted for the outcomes of interest.
resultsThe literature search identified 423 unique studies. Of which, only eight studies were eligible and included in the final review. Only vitamin D deficiency (VDD) was observed among these eight studies. There were no eligible studies that focused on the association between other single micronutrient deficiency and ARI. The review found mixed observations on ARI incidence, and a lack of evidence on its associated severity to conclude the association between VDD and these outcomes. However, existing evidence consistently suggested that VDD is likely to lead to longer ARI duration (median duration in days: deficient group, 4 to 13; non-deficient groups, 2 to 8).
conclusionThis review found that VDD may be associated to longer ARI duration, but its effect on ARI incidence and its associated severity among healthy adults remains inconclusive. This review also highlighted the lack of a consistent regional and/or global definition for micronutrient sufficiency, and that future studies should explore and conclude the association between other micronutrient deficiency and ARIs in healthy adults before considering supplementation for ARI prevention and management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.