Evidence map›Paper›PMID 31785183›Full record

ArticleArthritis care & research2021

Family History of Rheumatic, Autoimmune, and Nonautoimmune Diseases and Risk of Rheumatoid Arthritis.

Vanessa L Kronzer, Cynthia S Crowson, Jeffrey A Sparks, Elena Myasoedova, John Davis

Open access · greenAbstract read
In one paragraph

Article in Arthritis care & research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
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  5. Family History in the Context of CKD.Journal of the American Society of Nephrology : JASN · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Vanessa L KronzerMayo Clinic, Rochester, Minnesota.ORCID 0000-0002-7489-3134
Cynthia S CrowsonMayo Clinic, Rochester, Minnesota.ORCID 0000-0001-5847-7475
Jeffrey A SparksBrigham and Women's Hospital, Boston, Massachusetts.ORCID 0000-0002-5556-4618
Elena MyasoedovaMayo Clinic, Rochester, Minnesota.ORCID 0000-0003-2006-1436
John DavisMayo Clinic, Rochester, Minnesota.
Mayo Clinic · USBrigham and Women's Hospital · US

Funding

VERITY: Value and Evidence in Rheumatology using bioInformaTics, and advanced analYticsP30AR072577 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Daniel Hal Solomon · 2017 to 2026
$9.8M
Joint Biology Consortium Resource-based CenterP30AR070253 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Peter A Nigrovic, Jeffrey Andrew Sparks · 2016 to 2026
$9.4M
Rheumatoid Arthritis and Respiratory Outcomes in Prospective CohortsK23AR069688 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SPARKS, JEFFREY ANDREW · 2016 to 2020
$766k
Respiratory Diseases, Genetics, and Rheumatoid Arthritis RiskR03AR075886 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SPARKS, JEFFREY ANDREW · 2019 to 2020
$179k
NIAMS NIH HHS K23 AR069688NIAMS NIH HHS L30 AR066953NIAMS NIH HHS P30 AR070253NIAMS NIH HHS P30 AR072577NIAMS NIH HHS R03 AR075886
6 · The paper itself

Abstract

objectiveSince comorbidities such as autoimmune diseases may be associated with rheumatoid arthritis (RA) risk, we hypothesized that a family history of these other conditions might also predict RA. Therefore, we aimed to determine the association between family history of 79 comorbidities and RA.

methodsThis case-control study identified 821 cases of RA in the Mayo Clinic Biobank (positive predictive value 95%) and matched 3 controls to each case based on age, sex, recruitment year, and location. Patients self reported family history and characteristics (adjusted). Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs) for RA risk according to the presence of family history for each comorbidity, adjusted for body mass index, race, and smoking.

resultsFamily history of several conditions was associated with developing RA, including rheumatic autoimmune diseases (OR

conclusionFamily history of several autoimmune and nonautoimmune comorbidities was associated with increased risk of RA, providing an opportunity to identify novel populations at risk for RA.

Indexed as

Medical History TakingAgedArthritis, RheumatoidAutoimmune DiseasesCase-Control StudiesComorbidityFemaleHumansIncidenceMaleMiddle AgedRheumatic DiseasesRisk AssessmentRisk Factors

Identifiers

PMID31785183
PMCPMC7260093
OpenAlexW2989660548

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.