ArticleAging2019
T cells and immune functions of plasma extracellular vesicles are differentially modulated from adults to centenarians.
Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- The role of ginseng in aging: Insights into regulatory T cells activation and mitochondrial regulation.Journal of ginseng research · 2025Review
- Associations of age and sex with characteristics of extracellular vesicles and protein-enriched fractions of blood plasma.Aging cell · 2025Article
- Aging-dependent immunological changes in multiple sclerosis.Frontiers in immunology · 2025Article
- Age- and sex-related variations in extracellular vesicle profiling for the assessment of cardiovascular risk: the EVaging index.npj aging · 2024Article
- Review
- The Double-Edged Role of Extracellular Vesicles in the Hallmarks of Aging.Biomolecules · 2023Review
- Centenarians Alleviate Inflammaging by Changing the Ratio and Secretory Phenotypes of T Helper 17 and Regulatory T Cells.Frontiers in pharmacology · 2022Article
- Influences of age, race, and sex on extracellular vesicle characteristics.Theranostics · 2022Review
- Blood cell-derived extracellular vesicles: diagnostic biomarkers and smart delivery systems.Bioengineered · 2021Article
- Extracellular Vesicles in Blood: Sources, Effects, and Applications.International journal of molecular sciences · 2021Review
- Immunosenescence is both functional/adaptive and dysfunctional/maladaptive.Seminars in immunopathology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging is a universal and complex process that affects all tissues and cells types, including immune cells, in a process known as immunosenescence. However, many aspects of immunosenescence are not completely understood, as the characteristics of the immune cells of nonagenarians and centenarians or the features and implications of extracellular vesicles (EVs). In this study, we analyzed blood samples from 51 individuals aged 20-49 and 70-104 years. We found that senescent CD8 cells accumulate with age, while there is a partial reduction of senescent CD4 cells in nonagenarians and centenarians. Moreover, plasma EVs carry T cell specific markers, but no accumulation of "senescent-like EVs" was found within any of analyzed age groups. Our functional studies of cocultures of peripheral blood mononuclear cells and EVs showed that EVs enhance T cell viability and, under phytohemagglutinin stimulation, they influence cytokine secretion and cell activation in an age-dependent manner. These results underline the importance of EVs on the immune system functioning, and open new perspectives to further study their implication in human aging.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.