ArticleArthritis & rheumatology (Hoboken, N.J.)2020
Using Cumulative Load to Explain How Body Mass Index and Daily Walking Relate to Worsening Knee Cartilage Damage Over Two Years: The MOST Study.
Article in Arthritis & rheumatology (Hoboken, N.J.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Experiences of activity monitoring and perceptions of digital support among working individuals with hip and knee osteoarthritis - a focus group study.BMC public health · 2022Trial
- Obesity-induced oleic acid metabolic dysregulation may exacerbate osteoarthritis through the degradation of SOX9.Cellular and molecular life sciences : CMLS · 2026Article
- Physical Activity and 4-Year Radiographic Medial Joint Space Loss in Knee Osteoarthritis: A Joint Model Analysis.The Journal of bone and joint surgery. American volume · 2026Article
- Revisiting the Subtle Relationship Between Metabolic Syndrome and Osteoarthritis.Journal of inflammation research · 2026Review
- Peak, cumulative and rate of medial and lateral compartment joint loading during gait following total knee arthroplasty.Gait & posture · 2025Article
- Association between body weight fluctuation and progression of radiographic knee osteoarthritis: a longitudinal cohort study.RMD open · 2025Article
- Biomechanical effects of medial osteoarthritis progression and UKA on knee lateral compartment using fibril-reinforced biphasic material in finite element study.Scientific reports · 2025Article
- The relation of walking forces to structural damage in the knee: The Multicenter Osteoarthritis Study.Osteoarthritis and cartilage · 2025Article
- The Organ-Joint Axes in Osteoarthritis: Significant Pathogenesis and Therapeutic Targets.Aging and disease · 2024Review
- Interactions of cumulative load with biomarkers of cartilage turnover predict knee cartilage change over 2 years: data from the osteoarthritis initiative.Clinical rheumatology · 2024Article
- Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms.Bone research · 2023Review
- Gait, physical activity and tibiofemoral cartilage damage: a longitudinal machine learning analysis in the Multicenter Osteoarthritis Study.British journal of sports medicine · 2023Article
- Stepping Forward: A Scoping Review of Physical Activity in Osteoarthritis.The Journal of rheumatology · 2023Article
- Article
- Molecular Assessment of Healthy Pathological Articular Cartilages in Physically Active People: A Scoping Review.International journal of molecular sciences · 2023Article
- Association Between Walking for Exercise and Symptomatic and Structural Progression in Individuals With Knee Osteoarthritis: Data From the Osteoarthritis Initiative Cohort.Arthritis & rheumatology (Hoboken, N.J.) · 2022Observational
- How Physical Activity Affects Knee Cartilage and a Standard Intervention Procedure for an Exercise Program: A Systematic Review.Healthcare (Basel, Switzerland) · 2022Review
- Walking, running, and recreational sports for knee osteoarthritis: An overview of the evidence.European journal of rheumatology · 2022Article
- Linking Gait Biomechanics and Daily Steps After ACL Reconstruction.Medicine and science in sports and exercise · 2022Article
- Patellofemoral contact forces after ACL reconstruction: A longitudinal study.Journal of biomechanics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
objectiveKnee cartilage damage is often linked to mechanical overloading. However, cartilage requires mechanical load to remain healthy, suggesting that underloading may be detrimental. This study was undertaken to examine knee overloading and underloading by defining cumulative load as the joint effects of body mass index (BMI) and daily walking, and examine the relationship between cumulative load and worsening cartilage damage over 2 years.
methodsWe used data from the Multicenter Osteoarthritis Study. Steps/day, measured by accelerometry, and BMI were calculated at the 60-month visit. Cartilage damage on magnetic resonance imaging was semiquantitatively scored using the Whole-Organ Magnetic Resonance Imaging Score (WORMS) at the 60-month and 84-month visits; worsening damage was defined as increased WORMS between visits. Risk ratios (RRs) and 95% confidence intervals (95% CIs) were calculated using binomial regression, with adjustment for potential confounders.
resultsOur study included 964 participants, 62% of whom were female, with a mean ± SD age of 66.9 ± 7.5 years. Participants had a mean ± SD BMI of 29.7 ± 4.8 kg/m
conclusionThis study provides preliminary evidence that both overloading and underloading may be detrimental to medial TF cartilage, and underloading may be detrimental to lateral PF cartilage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.