ArticleHuman brain mapping2020
Pain modulates neural responses to reward in the medial prefrontal cortex.
Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Brain functional changes following spinal manipulation therapy in patients with lumbar disc herniation and chronic low back pain: a scoping review.Frontiers in neurology · 2025Pooled it
- Punishments Enhance Reward Learning by Modulating Striatal Prediction Errors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Preemptive transcranial direct current stimulation mitigates susceptibility to persistent pain.Communications biology · 2025Article
- The analgesic effect and neural mechanism of spicy food intake.Social cognitive and affective neuroscience · 2025Article
- Cortical functional connectivity and topology based on complex network graph theory analysis during acute pain stimuli.Neurophotonics · 2025Article
- Article
- Incidental physical pain reduces brain activities associated with affective social feedback and increases aggression.Social cognitive and affective neuroscience · 2023Article
- Relationship between behavioral and mood responses to monetary rewards in a sample of Indian students with and without reported pain.Scientific reports · 2022Article
- EGR3 regulates opioid-related nociception and motivation in male rats.Psychopharmacology · 2022Article
- Effect of music intervention on subjective scores, heart rate variability, and prefrontal hemodynamics in patients with chronic pain.Frontiers in human neuroscience · 2022Article
- Electrophysiological evidence for the effects of pain on the different stages of reward evaluation under a purchasing situation.Frontiers in psychology · 2022Article
- The Distinct Functions of Dopaminergic Receptors on Pain Modulation: A Narrative Review.Neural plasticity · 2021Review
- Pain modulates neural responses to reward in the medial prefrontal cortex.Human brain mapping · 2020Article
- Pain Modulates Responses to Emotional Stimuli.Frontiers in psychology · 2020Article
- Neural Responses to Reward in a Gambling Task: Sex Differences and Individual Variation in Reward-Driven Impulsivity.Cerebral cortex communications · 2020Article
- The association of spouse interactions and emotional learning in interference related to chronic back pain.Neurobiology of pain (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pain has been found to promote reward-seeking behaviors, which might be a consequence of modulated brain activities in the reward neural circuitry in a painful state. The present study investigated how pain affected reward processing and reward-related neural activities using fMRI technique. A total of 50 healthy participants were recruited and used for data analyses, with half being treated with topical capsaicin cream and the other half with hand cream (treatment: pain or control). The participants were asked to perform a card-guessing game when their brain activities responding to feedbacks (outcome: win or loss) were recorded. Behavioral results showed that participants in pain group overestimated their correct choices in the card-guess game. Whole-brain fMRI analysis revealed that the main effect of outcome (win vs. loss) activated a typical network of the reward neural circuitry, including the medial prefrontal cortex (mPFC) and the bilateral nucleus accumbens (NAcc). Importantly, the region of interest analysis revealed a significant interaction of treatment and outcome in the mPFC, with increased mPFC neural activity responding to win outcome in pain condition. Moreover, the functional connectivity between the mPFC and the NAcc was decreased in pain condition. We conclude that the pain-induced modulation of the mPFC activity could result in alterations of both the emotional response to and the cognitive evaluation of reward.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.