ArticleHuman brain mapping2020
Sensitivity of ventrolateral posterior thalamic nucleus to back pain in alcoholism and CD4 nadir in HIV.
Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 35 citations in OpenAlex.
- Differential alterations of thalamic subregions in children and adolescents with attention deficit hyperactivity disorder and comorbid internalizing/externalizing disorders.BMC psychiatry · 2025Article
- Sex differences in the neuroimmune response following heavy, binge-like alcohol exposure in adolescent rats.Journal of neuroimmunology · 2025Article
- Comprehensive Segmentation of Deep Grey Nuclei From Structural MRI Data.Human brain mapping · 2025Article
- Ventral Anterior-Lateral Complex of the Thalamus Mediates Chronic Stress-Induced Pain Hypersensitivity and Underlies Electroacupuncture Analgesia.Brain and behavior · 2025Article
- Normative Modeling of Thalamic Nuclear Volumes and Characterization of Lateralized Volume Alterations in Alzheimer's Disease Versus Schizophrenia.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- All Blood Brain Barrier Cell Types Demonstrate Capability to Influence Differential Tenofovir and Emtricitabine Metabolism and Transport in the Brain.ACS pharmacology & translational science · 2024Article
- Drug Metabolism and Transport Capacity of Endothelial Cells, Pericytes, and Astrocytes: Implications for CNS Drug Disposition.bioRxiv : the preprint server for biology · 2024Article
- Robust thalamic nuclei segmentation from T1-weighted MRI using polynomial intensity transformation.Brain structure & function · 2024Article
- Thalamic nuclei segmentation from T1-weighted MRI: Unifying and benchmarking state-of-the-art methods.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Normative modeling of thalamic nuclear volumes.medRxiv : the preprint server for health sciences · 2024Article
- Aging, HIV infection, and alcohol exert synergist effects on regional thalamic volumes resulting in functional impairment.NeuroImage. Clinical · 2024Article
- Self-Reported Pain and Pain Observations in People with Korsakoff's Syndrome: A Pilot Study.Journal of clinical medicine · 2023Article
- Alcohol use disorder: Neuroimaging evidence for accelerated aging of brain morphology and hypothesized contribution to age-related dementia.Alcohol (Fayetteville, N.Y.) · 2023Review
- Multi-atlas thalamic nuclei segmentation on standard T1-weighed MRI with application to normal aging.Human brain mapping · 2023Article
- Thalamic nuclei atrophy at high and heterogenous rates during cognitively unimpaired human aging.NeuroImage · 2022Article
- Alcohol Use Disorder and Its Comorbidity With HIV Infection Disrupts Anterior Cingulate Cortex Functional Connectivity.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- Convolutional Neural Network Based Frameworks for Fast Automatic Segmentation of Thalamic Nuclei from Native and Synthesized Contrast Structural MRI.Neuroinformatics · 2022Article
- Altered Cerebro-Cerebellar Dynamic Functional Connectivity in Alcohol Use Disorder: a Resting-State fMRI Study.Cerebellum (London, England) · 2021Article
- In vivo high-resolution structural MRI-based atlas of human thalamic nuclei.Scientific data · 2021Article
- Attenuated cerebral blood flow in frontolimbic and insular cortices in Alcohol Use Disorder: Relation to working memory.Journal of psychiatric research · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Volumes of thalamic nuclei are differentially affected by disease-related processes including alcoholism and human immunodeficiency virus (HIV) infection. This MRI study included 41 individuals diagnosed with alcohol use disorders (AUD, 12 women), 17 individuals infected with HIV (eight women), and 49 healthy controls (24 women) aged 39 to 75 years. A specialized, high-resolution acquisition protocol enabled parcellation of five thalamic nuclei: anterior [anterior ventral (AV)], posterior [pulvinar (Pul)], medial [mediodorsal (MD)], and ventral [including ventral lateral posterior (VLp) and ventral posterior lateral (VPl)]. An omnibus mixed-model approach solving for volume considered the "fixed effects" of nuclei, diagnosis, and their interaction while covarying for hemisphere, sex, age, and supratentorial volume (svol). The volume by diagnosis interaction term was significant; the effects of hemisphere and sex were negligible. Follow-up mixed-model tests thus evaluated the combined (left + right) volume of each nucleus separately for effects of diagnosis while controlling for age and svol. Only the VLp showed diagnoses effects and was smaller in the AUD (p = .04) and HIV (p = .0003) groups relative to the control group. In the AUD group, chronic back pain (p = .008) and impaired deep tendon ankle reflex (p = .0005) were associated with smaller VLp volume. In the HIV group, lower CD4 nadir (p = .008) was associated with smaller VLp volume. These results suggest that the VLp is differentially sensitive to disease processes associated with AUD and HIV.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.