Observational studyLa Radiologia medica2020
Late iodine enhancement cardiac computed tomography for detection of myocardial scars: impact of experience in the clinical practice.
Observational study in La Radiologia medica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06964672 (Advanced Imaging With Photon Counting Computed Tomography in Heart Failure Patients), which is not on this map. Cited by 56 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Advanced Imaging With Photon Counting Computed Tomography in Heart Failure Patients: a Prospective Study
Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Diagnostic accuracy of late iodine enhancement on cardiac CT for myocardial tissue characterization: a systematic review and meta-analysis.European radiology · 2025Pooled it
- The current landscape of imaging recommendations in cardiovascular clinical guidelines: toward an imaging-guided precision medicine.La Radiologia medica · 2020Pooled it
- The role of cardiac CT with late iodine enhancement in patients with acute cardiac symptoms and troponin elevation in the era of high-sensitivity assays.European radiology · 2026Article
- Imaging phenotypes and substrates in ventricular tachycardia.Herzschrittmachertherapie & Elektrophysiologie · 2026Review
- Image-quality optimization for late iodine enhancement with photon-counting CT: impact of spectral analysis and reconstruction parameters.La Radiologia medica · 2026Article
- Diagnostic Value and Operational Recommendations for Late Iodine Enhancement and ECV Quantification in Single-Energy Computed Tomography: A Narrative Review.Diagnostics (Basel, Switzerland) · 2026Review
- Calculation of Ejection Fraction Using Cardiac Computed Tomography: Clinical Evolution, Reliability, and Technological Challenges-A Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- Improved image quality and greater diagnostic suitability in myocardial delayed enhancement CT with deep learning image reconstruction.Japanese journal of radiology · 2026Article
- Non-Dilated Left Ventricular Cardiomyopathy (NDLVC): A Name, Multiple Souls.Current cardiology reports · 2026Review
- Cardiac CT for the Assessment of Ischemic Cardiomyopathy.Journal of the Korean Society of Radiology · 2026Review
- Ultrafast non-ECG-gated cardiac spectral CT scanning for myocardial late iodine enhancement assessment: a feasibility study.La Radiologia medica · 2026Article
- Clinical application of cardiac computed tomography in cardiomyopathy.The international journal of cardiovascular imaging · 2026Review
- SIRM/SIC consensus document on the management of patients with acute chest pain.La Radiologia medica · 2025Article
- Evolution of Human Scar-Related Ventricular Tachycardia Mapping for Exploring Mechanisms of Reentry Circuits.Reviews in cardiovascular medicine · 2025Review
- CT acquisition protocols by pathology, SIRM position paper part 1: head and neck, brain and spine, chest, cardiovascular.La Radiologia medica · 2025Article
- Radiomics Signature of Aging Myocardium in Cardiac Photon-Counting Computed Tomography.Diagnostics (Basel, Switzerland) · 2025Article
- Use of Electron Density Maps and Fused Images in Dual-Energy Cardiac Computed Tomography to Facilitate Detection of Late Iodine Enhancement.Circulation reports · 2025Article
- State of the art of CT myocardial perfusion.La Radiologia medica · 2025Review
- Comprehensive CT study to assess local and systemic involvement in patients with infective endocarditis: experience from a multidisciplinary team of a tertiary referral center.La Radiologia medica · 2025Article
- A new application of computed tomography: stereotactic radiotherapy in the treatment of ventricular arrhythmias.European heart journal supplements : journal of the European Society of Cardiology · 2025Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCardiac CT with late iodine enhancement (LIE-CT) may characterize the scarred myocardium, but the role of readers' experience and scar pattern on LIE-CT diagnostic performance is unknown. Aim was to assess the diagnostic performance of LIE-CT according to readers' experience, scar pattern and contrast-to-noise ratio (CNR) using late gadolinium enhancement MRI (LGE-MRI) as reference.
methodsLIE-CT and LGE-MRI images of 40 consecutive patients were analyzed. Two readers with different experience (8 and 2 years) independently analyzed LIE-CT images defining the presence/absence of scar and scar CNR, segmental involvement, transmural pattern and scar etiology. The same parameters were extracted from LGE-MRI by two expert readers in consensus, blinded to the LIE-CT results.
resultsScars were identified at LGE-MRI in 29/40 patients and 141/680 segments. Scar burden at LIE-CT versus LGE-MRI correlated better for the most experienced reader than for the least experienced one (ρ = 0.954 and ρ = 0.797, p < 0.001). The most experienced reader missed scars in 2 patients and in 21/141 segments; the least experienced in 5 patients and 53/141 segments. The most experienced reader showed higher accuracy and sensitivity compared to the least experienced in per-patient (accuracy: 95% vs. 88%; sensitivity: 93% vs. 83%) and per-segment analysis (accuracy: 96% vs. 92%; sensitivity: 85% vs. 62%). Specificity was excellent (100% per-patient, 99% per-segment,) regardless of readers' experience. Missed scars had non-ischemic pattern, low scar burden (< 6%) and lower CNR compared to ischemic scars (2.33 vs. 3.54, p = 0.005).
conclusionLIE-CT represents an alternative to LGE-MRI, although the impact of readers' experience on sensitivity for small non-ischemic scars should be considered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.