ArticleEndocrine2020
Effects of low extracellular sodium on proliferation and invasive activity of cancer cells in vitro.
Article in Endocrine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 19 citations in OpenAlex.
- Whole peritoneal radiotherapy in malignant ascites: a hypothesis-generating conceptual review.Open medicine (Warsaw, Poland) · 2026Review
- Effects of reduced extracellular sodium on proliferation and invasive activity of renal cell carcinoma cell lines.Scientific reports · 2025Article
- Review
- Vitamins and minerals and their role in cancer: a comprehensive review.Frontiers in nutrition · 2025Review
- Effects of Reduced Extracellular Sodium Concentrations on Cisplatin Treatment in Human Tumor Cells: The Role of Autophagy.International journal of molecular sciences · 2024Article
- Hyponatremia Promotes Cancer Growth in a Murine Xenograft Model of Neuroblastoma.International journal of molecular sciences · 2023Article
- Hyponatremia-related liver steatofibrosis and impaired spermatogenesis: evidence from a mouse model of the syndrome of inappropriate antidiuresis.Journal of endocrinological investigation · 2023Article
- Hyponatremia and Cancer: From Bedside to Benchside.Cancers · 2023Review
- The VJournal of endocrinological investigation · 2022Article
- Hyponatremia and Oxidative Stress.Antioxidants (Basel, Switzerland) · 2021Review
- Serum sodium alterations in SARS CoV-2 (COVID-19) infection: impact on patient outcome.European journal of endocrinology · 2021Observational
- Lower Serum Sodium Levels Are Associated with the Therapeutic Effect of Sorafenib on Hepatocellular Carcinoma.Digestive diseases and sciences · 2021Article
- miR-497-5p induces apoptosis in K562 cells by downregulating ROCK1.American journal of translational research · 2021Article
- Antioxidant Efficacy of Olive By-Product Extracts in Human Colon HCT8 Cells.Foods (Basel, Switzerland) · 2020Article
- Hyponatremia in Patients with Hematologic Diseases.Journal of clinical medicine · 2020Review
- Integration of a 4-gene risk score model enhances prognostic accuracy in acute myeloid leukemia.Cell cycle (Georgetown, Tex.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeHyponatremia is the most common electrolyte disorder in hospitalized patients, and its etiopathogenesis is related to an underlying tumor in 14% of cases. Hyponatremia has been associated with a worse outcome in several pathologies, including cancer, in which the leading cause of this electrolyte alteration is the syndrome of inappropriate antidiuresis. The aim of this study was to analyze in vitro the effects of low extracellular [Na MATERIALS AND
methodsWe used a previously validated experimental model of chronic hyponatremia to characterize the effects of low extracellular [Na
resultsOur results demonstrate a direct relationship between low [Na
conclusionsOverall, our data demonstrate for the first time that low [Na
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.