Evidence map›Paper›PMID 31784840›Full record

ArticleJournal of materials science. Materials in medicine2019

Adhesion, proliferation and differentiation of human mesenchymal stem cell on chitosan/collagen composite scaffold.

Md Abdul Kafi, Mst Khudishta Aktar, Yos Phanny, Mitsugu Todo

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of materials science. Materials in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 52 citations in OpenAlex.

  1. Biomimetic Scaffold of Chitosan fromAdvanced pharmaceutical bulletin · 2026
    Article
  2. Review
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  7. Green Synthesized Chitosan Nanoparticles for Controlling Multidrug-ResistantInternational journal of molecular sciences · 2024
    Article
  8. Article
  9. Article
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  13. Closer to Nature: The Role of MSCs in Recreating the Microenvironment of the Hematopoietic Stem Cell Niche in vitro.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2022
    Review
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  16. Article
  17. Article
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  19. Article
  20. Collagen at the maternal-fetal interface in human pregnancy.International journal of biological sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Md Abdul KafiDepartment of Microbiology and Hygiene, Bangladesh Agricultural University, Mymensigh, 2202, Bangladesh. makafi2003@bau.edu.bd.ORCID http://orcid.org/0000-0001-8126-024X
Mst Khudishta AktarDepartment of Microbiology and Hygiene, Bangladesh Agricultural University, Mymensigh, 2202, Bangladesh.
Yos PhannyInterdisciplinary Graduate School of Engineering Sciences, Kyushu University, Kasuga, Fukuoka, Japan.
Mitsugu TodoResearch Institute for Applied Mechanics, Kyushu University, Kasuga, Fukuoka, Japan.
Kyushu University · JP

Funding

Japan Society for the Promotion of Science 24•02380
6 · The paper itself

Abstract

In vitro tissue engineering requires a progenitor cell source and a porous scaffold providing three dimensional (3D) supports for growth and differentiation to attain tissue architectures. This research focused on fabrication and characterization of 3D porous scaffolds using chitosan (CS), collagen (CG) and chitosan-collagen (CS-CG) composite to investigate their influence on human mesenchymal stem cell (hMSC) adhesion, proliferation and differentiation. Material dependent variations in porous morphology and mechanical behavior of the fabricated CS, CG and CS-CG scaffold showed significant impact on hMSC adhesion, proliferation and differentiation. The maximum hMSC adhesion and proliferation was reported on CS-CG scaffold among all fabricated scaffold groups. Interconnectivity of pores structure in CS-CG scaffold was considered as preferable attribute for such enhanced growth and distribution throughout the scaffold. Besides, CS scaffold with well interconnected pores showed poor adhesion and proliferation because of inadequate adhesion motifs. In case of CG scaffold, optimum growth and distribution of hMSC occurs only at the surface because of the absence of interconnectivity in their pore structures. Likewise, osteogenic differentiation of hMSC occurs most preferably in CS-CG composite scaffold among all scaffold groups. Such enhanced hMSC proliferation and differentiation in CS-CG scaffold significantly influenced on mechanical behavior of scaffold which is essential for in vivo application of a bone tissue implant. Thus CS-CG composite scaffold holds promise to be a suitable platform for in vitro engineering of bone tissue implant.

Indexed as

Biocompatible MaterialsCell AdhesionCell ProliferationChitosanCollagenHumansMaterials TestingMesenchymal Stem CellsMicroscopy, Electron, ScanningTissue EngineeringTissue ScaffoldsBiocompatible MaterialsChitosanCollagen

Identifiers

PMID31784840
OpenAlexW2990688586

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.