ArticleScientific reports2019
Isolation and comparative genomics of Mycobacterium tuberculosis isolates from cattle and their attendants in South India.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Burden of Bovine Tuberculosis on Animal Health, Welfare and Production: A Systematic Review.Transboundary and emerging diseases · 2025Pooled it
- The ppsA-ppsE gene cluster in Mycobacterium bovis: structure, function, and role in virulence.Archives of microbiology · 2026Review
- Bovine tuberculosis resulting from infection with Mycobacterium orygis in a closed herd of Indian water buffalo (Bubalus bubalis).Scientific reports · 2026Article
- Recovery ofOpen forum infectious diseases · 2025Article
- A retrospective study of zoonotic tuberculosis among livestock farmers of Lahore district using one health approach.Journal of advanced veterinary and animal research · 2024Article
- Insights into mycobacteriome composition in Mycobacterium bovis-infected African buffalo (Syncerus caffer) tissue samples.Scientific reports · 2024Article
- Molecular detection and characterization of theMicrobiology spectrum · 2024Article
- Exploring virulence in Mycobacterium bovis: clues from comparative genomics and perspectives for the future.Irish veterinary journal · 2023Review
- Bovine tuberculosis in India: The need for One Health approach and the way forward.One health (Amsterdam, Netherlands) · 2023Review
- An Epidemic of Drug Resistance: Tuberculosis in the Twenty-First Century.Pathogens (Basel, Switzerland) · 2023Article
- Zoonotic tuberculosis in a high bovine tuberculosis burden area of Ethiopia.Frontiers in public health · 2023Article
- Article
- Review on Bovine Tuberculosis: An Emerging Disease Associated with Multidrug-ResistantPathogens (Basel, Switzerland) · 2022Review
- Macrophage-specific responses to human- and animal-adapted tubercle bacilli reveal pathogen and host factors driving multinucleated cell formation.PLoS pathogens · 2021Article
- Genome analyses of 174 strains ofMicrobial genomics · 2021Article
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Authors and funding
13 authors.
Funding
Abstract
The major human pathogen Mycobacterium tuberculosis is rarely reported to cause disease in other animals. Cases in livestock are thought to occur through contact with infected handlers, but previous studies evaluating putative livestock-human transmission used typing techniques with limited resolution. Here, we undertook cross-sectional surveillance for tuberculosis in 271 livestock handlers and 167 cattle on three farms in Chennai, India and defined the relatedness of cultured isolates using whole genome sequencing. Humans and livestock were screened for active mycobacterial infection, and opportunistic post-mortem examination was performed on comparative intradermal test-positive cattle that died. Four cattle and 6 handlers on two farms were culture-positive for M. tuberculosis; M. bovis was not isolated. All 10 isolates (one from each case) belonged to Lineage 1. Pairwise genome comparisons of single nucleotide polymorphism (SNP) differences ranged from 1 to 600 SNPs, but 3 isolate pairs were less than 5 SNPs different. Two pairs were from handlers and the third pair were from two cattle on the same farm. The minimum pairwise SNP difference between a cattle and human isolate was >250 SNPs. Our study confirms the presence of M. tuberculosis infection in cattle in India, sequencing of which characterised relatedness between human and cattle-derived isolates.
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