ArticleScientific reports2019
Influence of age and gender on the pulse waveform in optic nerve head circulation in healthy men and women.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Label-free in vivo molecular profiling of the human retina by non-resonant Raman spectroscopy.Communications biology · 2026Article
- Machine learning assessment of retinal blood flow links metabolic dysfunction and accelerated microvascular aging.Scientific reports · 2026Article
- The relationship between morphological and functional status and ocular blood flow in retinitis pigmentosa assessed by laser speckle flowgraphy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Investigation of Ocular Blood Flow in Males with Metabolic Syndrome.Diagnostics (Basel, Switzerland) · 2025Article
- Evaluation of ocular blood flow in the assessment of symptomatic carotid stenosis.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Novel superpixel method to visualize fundus blood flow resistivity in healthy adults.Scientific reports · 2023Article
- Characteristics of laterality in the optic nerve head microcirculation obtained by laser speckle flowgraphy in healthy subjects.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Article
- Characterization of laser speckle flowgraphy pulse waveform parameters for the evaluation of the optic nerve head and retinal circulation.Scientific reports · 2021Article
- Relative Retinal Blood Flow: A Novel and Informative Measure of Unilateral Retinal Vein Occlusion Severity.Translational vision science & technology · 2021Article
- Article
- Dynamic Alterations in Blood Flow in Glaucoma Measured with Laser Speckle Contrast Imaging.Ophthalmology. GlaucomaObservational
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The influences of age and gender differences on the pulse waveform in the optic nerve head (ONH) in healthy adults, using laser speckle flowgraphy (LSFG) were evaluated. We studied 908 healthy subjects (men = 701, age: 50.0 ± 9.1, women = 208, age: 49.8 ± 9.5, p = 0.76), evaluating these pulse waveform parameters: the blowout score (BOS), blowout time (BOT), acceleration time index (ATI), and the rising and falling rates. The parameters were analyzed separately for the tissue, vessels, and throughout the optic nerve head (All). All parameters were compared between genders. We investigated which independent factors for the pulse waveform in the ONH is most strongly correlated with age. All sections of the BOS, BOT, ATI, and falling rate showed a significant gender difference. A univariate regression analysis revealed that BOT-Tissue showed the strongest correlation with age (r = -0.51). The factors contributing independently to the BOT-Tissue were gender, age, heart rate, mean arterial blood pressure, pulse pressure, spherical refraction, and estimated glomerular filtration rate. Among the subjects aged >41 years, the chronological changes of BOT-Tissue in the women were significantly lower than those in the men. We concluded that the pulse waveform in the ONH has clear differences between the genders and shows chronological changes.
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