Evidence map›Paper›PMID 31784618›Full record

ArticleScientific reports2019

Laryngeal vibration as a non-invasive neuromodulation therapy for spasmodic dysphonia.

Sanaz Khosravani, Arash Mahnan, I-Ling Yeh, Joshua E Aman, Peter J Watson, Yang Zhang, George Goding, Jürgen Konczak

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03746509 (Laryngeal Vibration as a Non-invasive Treatment for Spasmodic Dysphonia), which is not on this map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03746509 nacompletednot on this map

Laryngeal Vibration as a Non-invasive Treatment for Spasmodic Dysphonia

TypeinterventionalSponsorUniversity of MinnesotaRan2019 to 2022Enrolled42ConditionsSpasmodic DysphoniaArmsLaryngeal Vibration (Treatment), Laryngeal Vibration (Comparator)
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 33 citations in OpenAlex.

  1. Good vibrations: Sternal vibration enhances white matter density and interoceptive awareness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Vibro-tactile stimulation of the neck reduces pain in people with cervical dystonia: a proof-of-concept study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. The shallow of your smile: the ethics of expressive vocal deep-fakes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Article
  18. Vibro-Tactile Stimulation as a Non-Invasive Neuromodulation Therapy for Cervical Dystonia: A Case Study.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2021
    Article
  19. Treatment of Dystonia: Medications, Neurotoxins, Neuromodulation, and Rehabilitation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Sanaz KhosravaniHuman Sensorimotor Control Laboratory, School of Kinesiology, University of Minnesota, Minnesota, USA.
Arash MahnanHuman Sensorimotor Control Laboratory, School of Kinesiology, University of Minnesota, Minnesota, USA.ORCID http://orcid.org/0000-0003-4097-9308
I-Ling YehHuman Sensorimotor Control Laboratory, School of Kinesiology, University of Minnesota, Minnesota, USA.
Joshua E AmanDepartment of Neurology, University of Minnesota, Minnesota, USA.
Peter J WatsonDepartment of Speech, Language, and Hearing Sciences, University of Minnesota, Minnesota, USA.
Yang ZhangDepartment of Speech, Language, and Hearing Sciences, University of Minnesota, Minnesota, USA.
George GodingDepartment of Otolaryngology, University of Minnesota, Minnesota, USA.
Jürgen KonczakHuman Sensorimotor Control Laboratory, School of Kinesiology, University of Minnesota, Minnesota, USA. jkonczak@umn.edu.ORCID http://orcid.org/0000-0002-4422-5610
University of Minnesota · US

Funding

Laryngeal vibration as a non-invasive treatment for spasmodic dysphoniaR01DC016315 · NIDCD · UNIVERSITY OF MINNESOTA · PI KONCZAK, JUERGEN · 2018 to 2020
$775k
Kinaesthetic Loss as a Marker for Spasmodic DysphoniaR21DC011841 · NIDCD · UNIVERSITY OF MINNESOTA · PI KONCZAK, JUERGEN, WATSON, PETER J · 2011 to 2012
$376k
NIDCD NIH HHS R01 DC016315NIDCD NIH HHS R21 DC011841
6 · The paper itself

Abstract

Spasmodic dysphonia (SD) is an incurable focal dystonia of the larynx that impairs speech and communication. Vibro-tactile stimulation (VTS) alters afferent proprioceptive input to sensorimotor cortex that controls speech. This proof-of-concept study examined the effect of laryngeal VTS on speech quality and cortical activity in 13 SD participants who vocalized the vowel /a/ while receiving VTS for 29 minutes. In response to VTS, 9 participants (69%) exhibited a reduction of voice breaks and/or a meaningful increase in smoothed cepstral peak prominence, an acoustic measure of voice/speech quality. Symptom improvements persisted for 20 minutes past VTS. Application of VTS induced a significant suppression of theta band power over the left somatosensory-motor cortex and a significant rise of gamma rhythm over right somatosensory-motor cortex. Such suppression of theta oscillations is observed in patients with cervical dystonia who apply effective sensory tricks, suggesting that VTS in SD may activate a similar neurophysiological mechanism. Results of this feasibility study indicate that laryngeal VTS modulates neuronal synchronization over sensorimotor cortex, which can induce short-term improvements in voice quality. The effects of long-term VTS and its optimal dosage for treating voice symptoms in SD are still unknown and require further systematic study.

Indexed as

AdultAgedDysphoniaFeasibility StudiesFemaleHumansLarynxMaleMiddle AgedPhysical Therapy ModalitiesPilot ProjectsSpeechVibrationVoiceVoice Quality

Identifiers

PMID31784618
PMCPMC6884515
OpenAlexW2989896597

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.