ArticleScientific reports2019
Enhancing the differentiation of specific genotypes in Mycobacterium tuberculosis population.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Variation in Mycobacterium tuberculosis population structure in Iran: a systemic review and meta-analysis.BMC infectious diseases · 2021Pooled it
- Heterogeneity of Mycobacterium tuberculosis Strains Circulating in Panama's Western Region.The American journal of tropical medicine and hygiene · 2023Article
- Genomic Diversity of the Rarely Observed Genotype of theMicroorganisms · 2023Article
- Strain-Specific Behavior of Mycobacterium tuberculosis in Interruption of Autophagy Pathway in Human Alveolar Type II Epithelial A549 CellsIranian biomedical journal · 2022Article
- The shortcut of mycobacterial interspersed repetitive unit-variable number tandem repeat typing forFrontiers in microbiology · 2022Article
- Distribution of molecular strains ofEpidemiology and infection · 2021Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Today, significant attention is directed towards the global lineages and sublineages of Mycobacterium tuberculosis (Mtb). NEW-1 (SIT 127) and CAS1-Delhi (SIT 26) strains are recognized as growing and circulating Mtb genotypes, especially in Asian countries. It is crucial to develop or enhance Mtb genotyping methods for a more accurate and simple differentiation of these families. We used 24-loci mycobacterial interspersed repetitive unit-variable number tandem repeat (MIRU-VNTR) typing for genotyping 217 Mtb isolates. To select the optimal MIRU-VNTR loci, we calculated the Hunter-Gaston discriminatory index (HGDI), allelic diversity, and accumulation of percentage differences (APDs) between the strains among different groups of genotypes (NEW-1 and non-NEW-1; CAS1-Delhi and non-CAS). Finally, the minimum spanning tree was constructed for clustering analysis. In the NEW-1 population, loci with APD > 60% were found to have a high discriminatory power. VNTR loci with APD > 50% showed high discrimination power for the CAS population. Our findings suggest that APDs, which are valuable for the selection of VNTR loci sets, may improve the discriminatory power of MIRU-VNTR typing for identification of Mtb genotypes in specific regions.
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