Evidence map›Paper›PMID 31784601›Full record

ArticleScientific reports2019

Detection of colonic neoplasia in vivo using near-infrared-labeled peptide targeting cMet.

Xiaoli Wu, Juan Zhou, Fa Wang, Xiaoqing Meng, Jing Chen, Tse-Shao Chang, Miki Lee, Gaoming Li, Xue Li, Henry D Appelman and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaoli WuDivision of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Juan ZhouDivision of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Fa WangDivision of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID http://orcid.org/0000-0002-0456-5207
Xiaoqing MengDivision of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Jing ChenDivision of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Tse-Shao ChangDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan, USA.ORCID http://orcid.org/0000-0003-1787-8744
Miki LeeDivision of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Gaoming LiDivision of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Xue LiDivision of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Henry D AppelmanDepartment of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
Rork KuickDepartment of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.ORCID http://orcid.org/0000-0002-8817-5192
Thomas D WangDivision of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA. thomaswa@umich.edu.ORCID http://orcid.org/0000-0001-9182-9620

Funding

Early Detection of Colorectal Cancer on Near-Infrared Molecular EndoscopyR01CA193377 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WANG, THOMAS D · 2016 to 2020
$2.1M
NCI NIH HHS R01 CA193377
6 · The paper itself

Abstract

White light colonoscopy is widely used to detect colorectal polyps, but flat and depressed lesions are often missed. Here, we report a molecular imaging strategy to potentially improve diagnostic performance by developing a fluorescently-labeled peptide specific for cMet. This 7mer is conjugated to Cy5.5, a near-infrared (NIR) cyanine dye. Specific binding to cMet was confirmed by cell staining, knockdown, and competition assays. The probe showed high binding affinity (k

Indexed as

AdenomaAnimalsCarbocyaninesCell Line, TumorColonic NeoplasmsColonoscopyFluorescent DyesHT29 CellsHumansImage-Guided BiopsyInfrared RaysIntestinal MucosaLigandsMiceNIH 3T3 CellsPeptidesCarbocyaninesCY5.5 cyanine dyeFluorescent DyesLigandsPeptidesProto-Oncogene Proteins c-met

Identifiers

PMID31784601
PMCPMC6884535

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.