Evidence map›Paper›PMID 31784582›Full record

ArticleScientific reports2019

Fine mapping and identification of serum urate loci in American Indians: The Strong Heart Family Study.

Geetha Chittoor, Karin Haack, Poojitha Balakrishnan, Christopher Bizon, Sandra Laston, Lyle G Best, Jean W MacCluer, Kari E North, Jason G Umans, Nora Franceschini and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 10 institutions in 3 countries.

Geetha ChittoorDepartment of Nutrition, and UNC Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, USA.
Karin HaackPopulation Health Program, Texas Biomedical Research Institute, San Antonio, TX, USA.
Poojitha BalakrishnanDepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, New York, USA.
Christopher BizonRenaissance Computing Institute, University of North Carolina, Chapel Hill, NC, USA.
Sandra LastonSouth Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX, USA.
Lyle G BestMissouri Breaks Industries Research Inc., Eagle Butte, SD, USA.
Jean W MacCluerPopulation Health Program, Texas Biomedical Research Institute, San Antonio, TX, USA.
Kari E NorthDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jason G UmansMedstar Health Research Institute, Hyattsville, MD, USA.
Nora FranceschiniDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Gauri PrasadGenomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, 110 020, India.
Luis Macias-KaufferLaboratorio de Enfermedades Cardiovasculares, INMEGEN, Mexico City, 14610, Mexico.ORCID http://orcid.org/0000-0002-3080-2835
Teresa Villarreal-MolinaLaboratorio de Enfermedades Cardiovasculares, INMEGEN, Mexico City, 14610, Mexico.
Dwaipayan BharadwajAcademy of Scientific and Innovative Research, CSIR-Institute of Genomics and Integrative Biology Campus, New Delhi, 110 020, India.
Samuel Canizales-QuinterosUnidad de Genomica de Poblaciones Aplicada a la Salud Facultad de Quimica, UNAM-Instituto Nacional de Medicina Genomica, Mexico City, Mexico.
Ana Navas-AcienDepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, New York, USA.
Shelley A ColePopulation Health Program, Texas Biomedical Research Institute, San Antonio, TX, USA.
V S VorugantiDepartment of Nutrition, and UNC Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, USA. saroja@unc.edu.
University of North Carolina at Chapel Hill · USNational Institute of Genomic Medicine · MXTexas Biomedical Research Institute · USColumbia University · USInstitute of Genomics and Integrative Biology · INJawaharlal Nehru University · INMedStar Health · USMissouri Breaks Industries Research (United States) · USRenaissance Computing Institute · USThe University of Texas Rio Grande Valley · US

Funding

Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3M
UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Venkata Saroja Voruganti · 1999 to 2026
$31.6M
Georgetown-Howard Universities Center for Clinical and Translational Science (GHUUL1TR000101 · NCATS · GEORGETOWN UNIVERSITY · PI MELLMAN, THOMAS A, VERBALIS, JOSEPH G · 2012 to 2015
$19.3M
The Strong Heart Study, Phase VU01HL041654 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI LEE, ELISA TAN · 1988 to 2013
$19.2M
CARDIOVASCULAR DISEASE IN THE PIMA INDIANSU01HL041642 · NHLBI · MEDSTAR RESEARCH INSTITUTE · PI HOWARD, BARBARA V · 1988 to 2013
$12.6M
STRONG HEART FAMILY STUDYU01HL065520 · NHLBI · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI COLE, SHELLEY A · 2000 to 2011
$8.9M
CARDIOVASCULAR DISEASE IN SIOUX INDIANSU01HL041652 · NHLBI · U.S. PHS INDIAN HEALTH SERVICE · PI BEST, LYLE G · 1988 to 2013
$7.9M
Quantitative Trait Locus Mapping in Human PedigreesR37MH059490 · NIMH · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI BLANGERO, JOHN · 2001 to 2010
$6.8M
SOLAR-Eclipse Computational Tools for Imaging GeneticsR01EB015611 · NIBIB · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KOCHUNOV, PETER V. · 2012 to 2024
$5.0M
CARDIOVASCULAR EVALUATION--STRONG HEART STUDY PHASE IVU01HL065521 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI DEVEREUX, RICHARD B · 2000 to 2013
$4.3M
Leveraging ancestry to map kidney lociR01MD012765 · NIMHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRANCESCHINI, NORA · 2017 to 2021
$3.6M
NCATS NIH HHS UL1 TR000101NCATS NIH HHS UL1 TR001409NHLBI NIH HHS R01 HL109301NHLBI NIH HHS R21 HL123677NHLBI NIH HHS R21 HL140385NHLBI NIH HHS U01 HL041642NHLBI NIH HHS U01 HL041652NHLBI NIH HHS U01 HL041654NHLBI NIH HHS U01 HL065520NHLBI NIH HHS U01 HL065521NIBIB NIH HHS R01 EB015611NIDDK NIH HHS P30 DK056350NIDDK NIH HHS R01 DK092238NIDDK NIH HHS R01 DK117445NIEHS NIH HHS P30 ES010126NIEHS NIH HHS R01 ES021367NIMHD NIH HHS R01 MD012765NIMH NIH HHS R01 MH059490NIMH NIH HHS R37 MH059490U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL109301U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) DK093228U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS) R01ES021367
6 · The paper itself

Abstract

While studies have reported genetic loci affecting serum urate (SU) concentrations, few studies have been conducted in minority populations. Our objective for this study was to identify genetic loci regulating SU in a multigenerational family-based cohort of American Indians, the Strong Heart Family Study (SHFS). We genotyped 162,718 single nucleotide polymorphisms (SNPs) in 2000 SHFS participants using an Illumina MetaboChip array. A genome-wide association analysis of SU was conducted using measured genotype analysis approach accounting for kinships in SOLAR, and meta-analysis in METAL. Our results showed strong association of SU with rs4481233, rs9998811, rs7696092 and rs13145758 (minor allele frequency (MAF) = 25-44%; P < 3 × 10

Indexed as

AdultAllelesAmerican Indian or Alaska NativeATP Binding Cassette Transporter, Subfamily G, Member 2Databases, GeneticFemaleGene FrequencyGenetic LociGenome-Wide Association StudyGenotypeGlucose Transport Proteins, FacilitativeHeartHumansLinkage DisequilibriumNeoplasm ProteinsNucleobindinsABCG2 protein, humanATP Binding Cassette Transporter, Subfamily G, Member 2Glucose Transport Proteins, FacilitativeNeoplasm ProteinsNUCB1 protein, humanNucleobindinsSLC2A9 protein, humanUric Acid

Identifiers

PMID31784582
PMCPMC6884539
OpenAlexW2990091519

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.