ArticleScientific reports2019
Statin treatment increases the clinical risk of tendinopathy through matrix metalloproteinase release - a cohort study design combined with an experimental study.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Effect of statins on the plasma/serum levels of inflammatory markers in patients with cardiovascular disease; a systematic review and meta-analysis of randomized clinical trials.Inflammopharmacology · 2022Pooled it
- The association between statin use and osteoarthritis-related outcomes: An updated systematic review and meta-analysis.Frontiers in pharmacology · 2022Pooled it
- An overview in tendon's physiology, pathomorphology, and treatment options.Cell and tissue research · 2026Review
- Unraveling the causality between carpal tunnel syndrome and trigger finger through genetic instrumental variables.European journal of medical research · 2025Article
- Investigating the controversy surrounding statin therapy and Achilles tendinopathy using Mendelian randomization analysis.International journal of clinical pharmacy · 2025Article
- The interplay between metabolic disorders and tendinopathies: Systematic review and meta-analysis.Journal of experimental orthopaedics · 2025Review
- Is Targeting LDL-C Levels Below 70 mg/dL Beneficial for Cardiovascular and Overall Health? A Critical Examination of the Evidence.Journal of clinical medicine · 2025Review
- Shoulder Tendinopathy Induced by Statins: A Case Report and Systematic Review.Journal of personalized medicine · 2025Article
- Hyperlipidemia and Rotator Cuff Tears: Exploring Mechanisms and Effective Treatment.Clinics in orthopedic surgery · 2025Review
- Elucidation of neutrophils-mediated effect of MMP-2 on lung epithelial cells; implications for acute respiratory distress syndrome and severe dengue pathogenesis.Frontiers in cellular and infection microbiology · 2025Article
- Association of Antihypertensive and Statin Medication Usage With Postoperative Stiffness After Arthroscopic Rotator Cuff Repair: A Retrospective Cohort Study.Orthopaedic journal of sports medicine · 2025Article
- Risk Factors for the Development of Olecranon Bursitis-A Large-Scale Population-Based Study.Journal of clinical medicine · 2024Article
- Prevalence of Tendon Rupture and Tendinopathies Among Patients with Atherosclerotic Cardiovascular Disease Derived From United States Administrative Claims Data.Cardiology and therapy · 2024Article
- Misconceptions about trigger finger: a scoping review. Definition, pathophysiology, site of lesion, etiology. Trigger finger solving a maze.Advances in rheumatology (London, England) · 2024Article
- Health-related factors and dysregulation of epigenetic related genes in metabolic syndrome trigger finger patients and smoker trigger finger patients: preliminary analysis of patient-derived sample.Journal of orthopaedic surgery and research · 2023Article
- Effects of Statin Treatment on the Development of Tendinopathy: A Nationwide Population-Based Cohort Study.Orthopaedic journal of sports medicine · 2023Article
- Review
- Exposure to oxLDL impairs TGF-β activity in human tendon cells.BMC musculoskeletal disorders · 2023Article
- Progress in studying the impact of hyperlipidemia and statins on rotator cuff injury and repair.Frontiers in public health · 2023Review
- Rotator Cuff Health, Pathology, and Repair in the Perspective of Hyperlipidemia.Journal of orthopaedics and sports medicine · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent experimental evidence indicates potential adverse effects of statin treatment on tendons but previous clinical studies are few and inconclusive. The aims of our study were, first, to determine whether statin use in a cohort design is associated with tendinopathy disorders, and second, to experimentally understand the pathogenesis of statin induced tendinopathy. We studied association between statin use and different tendon injuries in two population-based Swedish cohorts by time-dependent Cox regression analysis. Additionally, we tested simvastatin in a 3D cell culture model with human tenocytes. Compared with never-users, current users of statins had a higher incidence of trigger finger with adjusted hazard ratios (aHRs) of 1.50 for men (95% confidence interval [CI] 1.21-1.85) and 1.21 (1.02-1.43) for women. We also found a higher incidence of shoulder tendinopathy in both men (aHR 1.43; 1.24-1.65) and women (aHR 1.41; 0.97-2.05). Former users did not confer a higher risk of tendinopathies. In vitro experiments revealed an increased release of matrix metalloproteinase (MMP)-1 and MMP-13 and a weaker, disrupted matrix after simvastatin exposure. Current statin use seems to increase the risk of trigger finger and shoulder tendinopathy, possibly through increased MMP release, and subsequently, a weakened tendon matrix which will be more prone to injuries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.