Evidence map›Paper›PMID 31784536›Full record

ArticleNature communications2019

Transcription elongation factor AFF2/FMR2 regulates expression of expanded GGGGCC repeat-containing C9ORF72 allele in ALS/FTD.

Yeliz Yuva-Aydemir, Sandra Almeida, Gopinath Krishnan, Tania F Gendron, Fen-Biao Gao

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Decoding Nucleotide Repeat Expansion Diseases: Novel Insights fromInternational journal of molecular sciences · 2024
    Review
  10. Article
  11. Article
  12. Circulating blood circular RNA in Parkinson's Disease; a systematic study.medRxiv : the preprint server for health sciences · 2024
    Article
  13. Article
  14. GActa neuropathologica · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yeliz Yuva-AydemirDepartment of Neurology, University of Massachusetts Medical School, Worcester, MA, 01605, USA.
Sandra AlmeidaDepartment of Neurology, University of Massachusetts Medical School, Worcester, MA, 01605, USA. Sandra.almeida@umassmed.edu.ORCID http://orcid.org/0000-0002-5648-7239
Gopinath KrishnanDepartment of Neurology, University of Massachusetts Medical School, Worcester, MA, 01605, USA.
Tania F GendronDepartment of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.
Fen-Biao GaoDepartment of Neurology, University of Massachusetts Medical School, Worcester, MA, 01605, USA. fen-biao.gao@umassmed.edu.ORCID http://orcid.org/0000-0001-8873-5404
University of Massachusetts Chan Medical School · USMayo Clinic in Florida · US

Funding

Investigating Pathogenic Mechanisms of Frontotemporal Dementia Caused by Mutations in CHMP2B and TBK1R37NS057553 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GAO, FEN-BIAO · 2018 to 2024
$4.3M
Understanding Frontotemporal Dementia Using Drosophila and iPSC ModelsR01NS101986 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Fen-Biao Gao · 2017 to 2026
$3.6M
Prefrontal AMPA receptors in FTD PathogenesisR01NS093097 · NINDS · UPSTATE MEDICAL UNIVERSITY · PI GAO, FEN-BIAO, YAO, WEI-DONG · 2016 to 2020
$2.4M
Understanding Frontotemporal Dementia Using Drosophila and iPSC ModelsRF1NS101986 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GAO, FEN-BIAO · 2022 to 2022
$2.1M
Transmission Electron Microscope for Core EM FacilityS10RR027897 · NCRR · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CRAIG, ROGER W · 2009 to 2009
$500k
Inhibiting Translation of Endogenous G4C2-Containing RNA As a Novel Therapy for C9ORF72-ALSR21NS109847 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GAO, FEN-BIAO, RICHTER, JOEL D · 2018 to 2019
$461k
NCRR NIH HHS S10 RR027897NINDS NIH HHS R01 NS093097NINDS NIH HHS R01 NS101986NINDS NIH HHS R21 NS109847NINDS NIH HHS R37 NS057553NINDS NIH HHS RF1 NS101986
6 · The paper itself

Abstract

Expanded GGGGCC (G

Indexed as

AgedAged, 80 and overAmyotrophic Lateral SclerosisAnimalsAxonsC9orf72 ProteinDipeptidesDNA-Binding ProteinsDNA Repeat ExpansionDown-RegulationDrosophilaDrosophila ProteinsFemaleFrontotemporal DementiaGC Rich SequenceGene Knockout TechniquesAFF2 protein, humanC9orf72 ProteinDipeptidesDNA-Binding ProteinsDrosophila Proteinslilli protein, DrosophilaNuclear ProteinsTARDBP protein, humanTBPH protein, DrosophilaTranscription Factors

Identifiers

PMID31784536
PMCPMC6884579
OpenAlexW2991414201

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.