ArticleNature communications2019
Homogeneous cobalt-catalyzed reductive amination for synthesis of functionalized primary amines.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- A Highly Selective Cobalt Catalyst for Primary Amine Synthesis from Carboxylic Acids, Esters, and Vegetable Oils.Journal of the American Chemical Society · 2026Article
- Synthesis of Primary Amines via Reductive Amination of Aldehydes and Ketones Over a Ni-Doped MFM-300(Cr) Catalyst.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Late-stage modification of bioactive compounds: Improving druggability through efficient molecular editing.Acta pharmaceutica Sinica. B · 2024Review
- Chiral 8-Amino-5,6,7,8-tetrahydroquinoline Derivatives in Metal Catalysts for the Asymmetric Transfer Hydrogenation of 1-Aryl Substituted-3,4-dihydroisoquinolines as Alkaloids Precursors.Molecules (Basel, Switzerland) · 2023Article
- Branched Tertiary Amines from Aldehydes and α-Olefins by Combined Multiphase Tandem Reactions.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Article
- A Selective and General Cobalt-Catalyzed Hydroaminomethylation of Olefins to Amines.Angewandte Chemie (International ed. in English) · 2022Article
- Hydricity of 3d Transition Metal Complexes from Density Functional Theory: A Benchmarking Study.Molecules (Basel, Switzerland) · 2021Article
- Co-Catalyzed Synthesis of Primary Amines via Reductive Amination employing Hydrogen under very mild Conditions.ChemSusChem · 2021Article
- General and selective synthesis of primary amines using Ni-based homogeneous catalysts.Chemical science · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of earth abundant 3d metal-based catalysts continues to be an important goal of chemical research. In particular, the design of base metal complexes for reductive amination to produce primary amines remains as challenging. Here, we report the combination of cobalt and linear-triphos (bis(2-diphenylphosphinoethyl)phenylphosphine) as the molecularly-defined non-noble metal catalyst for the synthesis of linear and branched benzylic, heterocyclic and aliphatic primary amines from carbonyl compounds, gaseous ammonia and hydrogen in good to excellent yields. Noteworthy, this cobalt catalyst exhibits high selectivity and as a result the -NH
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