Evidence map›Paper›PMID 31784460›Full record

ArticleDevelopment (Cambridge, England)2019

The Paf1 complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors.

Michael J Jurynec, Xiaoying Bai, Brent W Bisgrove, Haley Jackson, Alex Nechiporuk, Rebecca A S Palu, Hannah A Grunwald, Yi-Chu Su, Kazuyuki Hoshijima, H Joseph Yost and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Rtf1 Transcriptionally Regulates Neonatal and Adult Cardiomyocyte Biology.Journal of cardiovascular development and disease · 2023
    Article
  5. The PAF1 complex cell autonomously promotes oogenesis in Caenorhabditis elegans.Genes to cells : devoted to molecular & cellular mechanisms · 2022
    Article
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Michael J JurynecDepartment of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0003-2702-9164
Xiaoying BaiStem Cell Program and Division of Hematology/Oncology, Children's Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Brent W BisgroveDepartment of Neurobiology and Anatomy, University of Utah, Salt Lake City, UT 84132, USA.
Haley JacksonDepartment of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-3326-5035
Alex NechiporukDepartment of Cell and Developmental Biology, School of Medicine, Oregon Health & Science University, Portland, OR 97239, USA.
Rebecca A S PaluDepartment of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA.
Hannah A GrunwaldDepartment of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-0553-906X
Yi-Chu SuDepartment of Neurobiology and Anatomy, University of Utah, Salt Lake City, UT 84132, USA.
Kazuyuki HoshijimaDepartment of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA.
H Joseph YostDepartment of Neurobiology and Anatomy, University of Utah, Salt Lake City, UT 84132, USA.ORCID 0000-0003-2961-5669
Leonard I ZonStem Cell Program and Division of Hematology/Oncology, Children's Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-0860-926X
David Jonah GrunwaldDepartment of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA grunwald@genetics.utah.edu.ORCID 0000-0002-6784-6647
University of Utah · USHoward Hughes Medical Institute · USOregon Health & Science University · US

Funding

UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI KATHARINE S ULLMAN · 1986 to 2026
$72.6M
Transcriptional mechanisms and melanomaP01CA163222 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI DAVID E FISHER · 2013 to 2026
$25.3M
Genome-wide Analysis of Cardiac Development in ZebrafishU01HL098160 · NHLBI · UNIVERSITY OF UTAH · PI YOST, H. JOSEPH · 2009 to 2014
$8.0M
Cancer Biology in the ZebrafishR01CA103846 · NCI · CHILDREN'S HOSPITAL BOSTON · PI ZON, LEONARD IRA · 2003 to 2022
$7.5M
ZEBRAFISH GENETICS COREP01HD048886 · NICHD · UNIVERSITY OF UTAH · PI GRUNWALD, DAVID J. · 2007 to 2011
$4.4M
Genome-Wide Analysis of Cardiac Development in ZebrafishUM1HL098160 · NHLBI · UNIVERSITY OF UTAH · PI YOST, H. JOSEPH · 2015 to 2019
$3.7M
A Toolkit for Gene-Targeting in ZebrafishR01HD081950 · NICHD · UNIVERSITY OF UTAH · PI GRUNWALD, DAVID J. · 2014 to 2018
$2.0M
NCI NIH HHS P01 CA163222NCI NIH HHS P30 CA042014NCI NIH HHS R01 CA103846NHLBI NIH HHS U01 HL098160NHLBI NIH HHS UM1 HL098160NICHD NIH HHS P01 HD048886NICHD NIH HHS R01 HD081950
6 · The paper itself

Abstract

Multipotent progenitor populations are necessary for generating diverse tissue types during embryogenesis. We show the RNA polymerase-associated factor 1 complex (Paf1C) is required to maintain multipotent progenitors of the neural crest (NC) lineage in zebrafish. Mutations affecting each Paf1C component result in near-identical NC phenotypes;

Indexed as

AnimalsAnimals, Genetically ModifiedBody PatterningCell DifferentiationCell LineageCyclin-Dependent Kinase 9Embryo, NonmammalianGene Expression Regulation, DevelopmentalMultipotent Stem CellsMultiprotein ComplexesNeural CrestNeural Stem CellsNuclear ProteinsPositive Transcriptional Elongation Factor BRNA Polymerase IITranscription FactorsCyclin-Dependent Kinase 9Multiprotein ComplexesNuclear Proteinspaf1 protein, zebrafishPositive Transcriptional Elongation Factor BRNA Polymerase IITranscription FactorsZebrafish ProteinsNeural crestPaf1 complexP-TEFbStem cellsTranscription pausingZebrafish mutant

Identifiers

PMID31784460
PMCPMC6955205
OpenAlexW2990273274

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.