ArticleDevelopment (Cambridge, England)2019
Neuronal differentiation influences progenitor arrangement in the vertebrate neuroepithelium.
Article in Development (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Cell division sets a universal flow geometry in cell layers.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Timely neurogenesis drives the transition from nematic to crystalline nuclear packing during retinal morphogenesis.Science advances · 2025Article
- Cellular signalling protrusions enable dynamic distant contacts in spinal cord neurogenesis.Biology open · 2025Article
- Dynamics of positional information in the vertebrate neural tube.Journal of the Royal Society, Interface · 2024Article
- Modelling variability and heterogeneity of EMT scenarios highlights nuclear positioning and protrusions as main drivers of extrusion.Nature communications · 2024Article
- Choice of friction coefficient deeply affects tissue behaviour in stochastic epithelial vertex models.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- The ECM and tissue architecture are major determinants of early invasion mediated by E-cadherin dysfunction.Communications biology · 2023Article
- Differential cell motion: A mathematical model of anterior posterior sorting.Biophysical journal · 2023Article
- The impact of cell size on morphogen gradient precision.Development (Cambridge, England) · 2023Article
- Article
- Synchronisation of apical constriction and cell cycle progression is a conserved behaviour of pseudostratified neuroepithelia informed by their tissue geometry.Developmental biology · 2023Article
- Cell cycle dynamics control fluidity of the developing mouse neuroepithelium.Nature physics · 2023Article
- A developmental pathway for epithelial-to-motoneuron transformation in C. elegans.Cell reports · 2022Article
- Regulation of size and scale in vertebrate spinal cord development.Wiley interdisciplinary reviews. Developmental biology · 2021Review
- Roadmap for the multiscale coupling of biochemical and mechanical signals during development.Physical biology · 2021Review
- From Cell States to Cell Fates: How Cell Proliferation and Neuronal Differentiation Are Coordinated During Embryonic Development.Frontiers in neuroscience · 2021Review
- Of mitogens and morphogens: modelling Sonic Hedgehog mechanisms in vertebrate development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 4 countries.
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Abstract
Cell division, movement and differentiation contribute to pattern formation in developing tissues. This is the case in the vertebrate neural tube, in which neurons differentiate in a characteristic pattern from a highly dynamic proliferating pseudostratified epithelium. To investigate how progenitor proliferation and differentiation affect cell arrangement and growth of the neural tube, we used experimental measurements to develop a mechanical model of the apical surface of the neuroepithelium that incorporates the effect of interkinetic nuclear movement and spatially varying rates of neuronal differentiation. Simulations predict that tissue growth and the shape of lineage-related clones of cells differ with the rate of differentiation. Growth is isotropic in regions of high differentiation, but dorsoventrally biased in regions of low differentiation. This is consistent with experimental observations. The absence of directional signalling in the simulations indicates that global mechanical constraints are sufficient to explain the observed differences in anisotropy. This provides insight into how the tissue growth rate affects cell dynamics and growth anisotropy and opens up possibilities to study the coupling between mechanics, pattern formation and growth in the neural tube.
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