Evidence map›Paper›PMID 31784092›Full record

ReviewSeminars in cell & developmental biology2020

Viscoelastic voyages - Biophysical perspectives on cell intercalation during Drosophila gastrulation.

Dinah Loerke, J Todd Blankenship

Abstract readReview
In one paragraph

Review in Seminars in cell & developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. The Enigmas of Tissue Closure: Inspiration fromCurrent issues in molecular biology · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. A PtdIns(3,4,5)PDevelopmental cell · 2021
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Dinah LoerkeDepartment of Physics and Astronomy, University of Denver, Denver, CO 80208, USA. Electronic address: dinah.loerke@du.edu.
J Todd BlankenshipDepartment of Biological Sciences, University of Denver, Denver, CO 80208, USA. Electronic address: todd.blankenship@du.edu.

Funding

Sliding vertex behaviors during epithelial morphogenesis and tissue elongationR01GM127447 · NIGMS · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI BLANKENSHIP, JAMES TODD, LOERKE, DINAH · 2018 to 2021
$1.2M
Mechanisms of membrane ratcheting during cell intercalationR15GM126422 · NIGMS · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI BLANKENSHIP, JAMES TODD · 2017 to 2017
$440k
The Biomechanics of Intercalation in Germ-Band ElongationR15GM117463 · NIGMS · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI LOERKE, DINAH · 2016 to 2016
$438k
NIGMS NIH HHS R01 GM127447NIGMS NIH HHS R15 GM117463NIGMS NIH HHS R15 GM126422
6 · The paper itself

Abstract

Developmental processes are driven by a combination of cytoplasmic, cortical, and surface-associated forces. However, teasing apart the contributions of these forces and how a viscoelastic cell responds has long been a key question in developmental biology. Recent advances in applying biophysical approaches to these questions is leading to a fundamentally new understanding of morphogenesis. In this review, we discuss how computational analysis of experimental findings and in silico modeling of Drosophila gastrulation processes has led to a deeper comprehension of the physical principles at work in the early embryo. We also summarize many of the emerging methodologies that permit biophysical analysis as well as those that provide direct and indirect measurements of force directions and magnitudes. Finally, we examine the multiple frameworks that have been used to model tissue and cellular behaviors.

Indexed as

GastrulationModels, BiologicalAnimalsDrosophila melanogasterEmbryo, MammalianViscoelastic SubstancesViscoelastic SubstancesBiophysicsCell intercalationDevelopmental biologyGastrulationMorphogenesis

Identifiers

PMID31784092
PMCPMC8274921

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.