Evidence map›Paper›PMID 31783924›Full record

ArticleJournal of health, population, and nutrition2019

Predictors of mortality among adult people living with HIV/AIDS on antiretroviral therapy at Suhul Hospital, Tigrai, Northern Ethiopia: a retrospective follow-up study.

Kebede Haile Misgina, Meresa Gebremedhin Weldu, Tewodros Haile Gebremariam, Negassie Berhe Weledehaweria, Haileslasie Berhane Alema, Yosef Sibhatu Gebregiorgis, Yonas Girma Tilahun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of health, population, and nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Kebede Haile MisginaCollege of Health Sciences, Aksum University, P.O. Box 1010, Aksum, Ethiopia.
Meresa Gebremedhin WelduCollege of Health Sciences, Aksum University, P.O. Box 1010, Aksum, Ethiopia. mere2010ec@yahoo.com.
Tewodros Haile GebremariamCollege of Health Science, Addis Ababa University, Addis Ababa, Ethiopia.
Negassie Berhe WeledehaweriaCollege of Health Sciences, Aksum University, P.O. Box 1010, Aksum, Ethiopia.
Haileslasie Berhane AlemaCollege of Health Sciences, Aksum University, P.O. Box 1010, Aksum, Ethiopia.
Yosef Sibhatu GebregiorgisCollege of Health Sciences, Aksum University, P.O. Box 1010, Aksum, Ethiopia.
Yonas Girma TilahunCenter of International Reproductive Health Training (CIRHT), Bahir Dar University, Bahir Dar, Ethiopia.
Aksum University · ETAddis Ababa University · ETBahir Dar University · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEthiopia is striving to achieve a goal of "zero human immune deficiency virus/acquired immune deficiency syndrome (HIV/AIDS)-related deaths." However, little has been documented on the factors that hamper the progress towards achieving this goal. Therefore, the ultimate aim of this study was to determine predictors of mortality among adult people living with HIV/AIDS on antiretroviral therapy (ART).

methodsA retrospective follow-up study was employed on all adult HIV/AIDS patients who started ART between January 1 and December 30, 2010, at Suhul Hospital, Tigrai Region, Northern Ethiopia. Data were collected by trained fourth-year Public Health students using a checklist. Finally, the collected data were entered into SPSS version 16. Then after, Kaplan-Meier curves were used to estimate survival probability, the log-rank test was used for comparing the survival status, and Cox proportional hazards model were applied to determine predictors of mortality.

resultsThe median follow-up period was 51 months (ranging between 1 and 60 months, inter-quartile range (IQR) = 14 months). At the end of follow-up, 37 (12.5%) patients were dead. The majority of these cumulative deaths, 19 (51.4%) and 29 (78.4%), occurred within 3 and 4 years of ART initiation respectively. Consuming alcohol (adjusted hazard ratio (AHR) = 2.23, 95% CI = 1.15, 4.32), low body weight (AHR = 2.38, 95% CI = 1.03, 5.54), presence of opportunistic infections (AHR = 2.18, 95% CI = 1.09, 4.37), advanced WHO clinical stage (AHR = 2.75, 95% CI = 1.36, 5.58), and not receiving isoniazid prophylactic therapy (AHR = 3.00, 95% CI = 1.33, 6.74) were found to be independent predictors of mortality.

conclusionThe overall mortality was very high. Baseline alcohol consumption, low body weight, advanced WHO clinical stage, the presence of opportunistic infections, and not receiving isoniazid prophylactic therapy were predictors of mortality. Strengthening behavioral and nutritional counseling with close clinical follow-up shall be given much more emphasis in the ART care and support program.

Indexed as

HIVAcquired Immunodeficiency SyndromeAdultAnti-HIV AgentsEthiopiaFemaleFollow-Up StudiesHIV InfectionsHumansKaplan-Meier EstimateMaleProportional Hazards ModelsRetrospective StudiesRisk FactorsAnti-HIV AgentsARTEthiopiaHIV/AIDSMortalityTigrai

Identifiers

PMID31783924
PMCPMC6883545
OpenAlexW2990922941

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.