ArticleVeterinary research2019
Differences in immune responses to Haemonchus contortus infection in the susceptible Ile de France and the resistant Santa Ines sheep under different anthelmintic treatments regimens.
Article in Veterinary research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 85 citations in OpenAlex.
- Comparison of Th-2 Cytokines and Associated Gene Expression in Peripheral Blood of Resistant and Susceptible Garole Sheep Infected WithJournal of parasitology research · 2026Article
- Immunopathological Changes Caused byPathogens (Basel, Switzerland) · 2025Article
- Comparative Study of Two Immunisation Protocols in Goats Using Thiol-Sepharose Chromatography-Enriched Extracts from AdultVaccines · 2025Article
- The adaptability of Garut sheep grazing on oil palm and rubber plantations in tropical conditions of Indonesia.Veterinary world · 2024Article
- Genetic Parameter Estimation and Selection for Resistance to Gastrointestinal Nematode Parasites in Sheep-A Review.Animals : an open access journal from MDPI · 2024Review
- Helminth Control Practices in Sheep and Cattle in Urban and Peri-Urban Areas of Adea District, Central Ethiopia.Veterinary medicine (Auckland, N.Z.) · 2024Article
- PLGA-EncapsulatedVaccines · 2023Article
- Influence of targeted selective anthelmintic treatment on the productive performance of wool and hair lambs naturally infected with gastrointestinal nematodes in Brazil.Veterinary research communications · 2023Article
- Antibody response and abomasal histopathology of lambs with haemonchosis during supplementation with medicinal plants and organic selenium.Veterinary and animal science · 2023Article
- Haemonchosis in Sheep and Goats, Control Strategies and Development of Vaccines againstAnimals : an open access journal from MDPI · 2022Review
- Development of Bovine Gastric Organoids as a NovelFrontiers in cellular and infection microbiology · 2022Article
- Ovarian activation delays in peripubertal ewe lambs infected with Haemonchus contortus can be avoided by supplementing protein in their diets.BMC veterinary research · 2021Article
- Cellular and humoral immune responses associated with protection in sheep vaccinated against Teladorsagia circumcincta.Veterinary research · 2021Article
- Physiological, Immunological and Genetic Factors in the Resistance and Susceptibility to Gastrointestinal Nematodes of Sheep in the Peripartum Period: A Review.Helminthologia · 2021Article
- Lymphoplasmacytic and eosinophilic enteritis with or without globule leukocyte hyperplasia in 4 goats.Journal of veterinary internal medicine · 2021Article
- Tuft Cells Increase Following Ovine Intestinal Parasite Infections and Define Evolutionarily Conserved and Divergent Responses.Frontiers in immunology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Understanding the immunological basis of resistance to gastrointestinal nematode infections in livestock is important in order to develop novel methods of parasite control such as vaccination or genetic selection for parasite resistance. The present study aimed to investigate differences in immune response between parasite resistant Santa Ines and susceptible Ile de France sheep breeds to natural Haemonchus contortus infection. Parasitological parameters, humoral immunity, local and circulating cellular immune responses were evaluated in 19 Santa Ines and 19 Ile de France lambs undergoing different anthelmintic treatments regimens: suppressive treatments (SUP) or targeted selective treatments (TST) over a 5-month grazing period. Santa Ines lambs had significantly lower Haemonchus faecal egg count and worm burden compared to Ile de France regardless of treatment regime. In addition, circulating blood eosinophils count and parasite-specific IgG levels were significantly higher and more rapidly induced in Santa Ines lambs. Abomasal immune responses were generally greater in the resistant breed, which had significantly higher levels of parasite-specific IgA in mucus, and elevated number of globule leukocytes and CD3+ T cells within the abomasal mucosal. Furthermore, numbers of POU2F3+ epithelial cells, a tuft-cell specific transcription factor, were also elevated in the Santa Ines breed, suggesting that this breed is better able to initiate T-helper type 2 immune responses within the abomasum. In conclusion, the differential immunological responses detailed here are relevant to understanding resistance to gastrointestinal nematodes in other host breeds, as well as to resistance breeding as a sustainable control approach for parasitic infections.
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