Evidence map›Paper›PMID 31783915›Full record

ArticleBMC research notes2019

Proteomic analysis of Nrk gene-disrupted placental tissue cells explains physiological significance of NRK.

Kimitoshi Denda, Kanako Ida, Masataka Tanno, Kanako Nakao-Wakabayashi, Masayuki Komada, Nobuhiro Hayashi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kimitoshi DendaSchool of Life Science and Technology, Tokyo Institute of Technology, (M6-6) 2-12-1 Ookayama, Meguro-ku, Tokyo, 152-8550, Japan.
Kanako IdaSchool of Life Science and Technology, Tokyo Institute of Technology, (M6-6) 2-12-1 Ookayama, Meguro-ku, Tokyo, 152-8550, Japan.
Masataka TannoDepartment of Pathology, Tokyo Nishi Tokushukai Hospital, Akishima, Japan.
Kanako Nakao-WakabayashiSchool of Life Science and Technology, Tokyo Institute of Technology, (M6-6) 2-12-1 Ookayama, Meguro-ku, Tokyo, 152-8550, Japan.
Masayuki KomadaCell Biology Unit, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, Japan.
Nobuhiro HayashiSchool of Life Science and Technology, Tokyo Institute of Technology, (M6-6) 2-12-1 Ookayama, Meguro-ku, Tokyo, 152-8550, Japan. nhayashi@bio.titech.ac.jp.ORCID http://orcid.org/0000-0002-9950-094X
Tokyo Institute of Technology · JP

Funding

Grants-in-aid from the Ministry of Education, Culture, Sports, Science, and Technology of Japan 15K14378Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province (CN) 21113505
6 · The paper itself

Abstract

objectiveNRK is a unique X chromosome-linked protein kinase expressed predominantly in placenta. The gene knockout causes placental overgrowth and delayed labor of Nrk-null fetuses from dams in mouse. To clarify unknown mechanisms behind the Nrk-null phenotypes, protein expression profiles were analyzed in the Nrk-null placenta using a high-performance two-dimensional electrophoresis methodology.

resultsAmong around 1800 spots detected, we characterized a dozen protein spots whose expression levels were significantly altered in the Nrk-null placenta compared to wild-type. Analyzing these data sets is expected to reflect the difference physiologically in the presence or absence of NRK, facilitating the development of therapeutic strategies.

Indexed as

ProteomicsAnimalsElectrophoresis, Gel, Two-DimensionalFemaleIntracellular Signaling Peptides and ProteinsMicePlacentaPregnancyProtein Serine-Threonine KinasesIntracellular Signaling Peptides and ProteinsNik related kinaseProtein Serine-Threonine KinasesBreast tumorDystociaPlacentaPlacentomegalyProtein kinase

Identifiers

PMID31783915
PMCPMC6884884
OpenAlexW2991297144

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.